A functional variant in the γ-glutamyltransferase (GGT)1 gene is associated with airflow obstruction in smokers

Morita, Kazunori; Masuda, Natsuki; Tanaka, Takahiro; Saruwatari, Junji; Oniki, Kentaro; Kajiwara, Ayami; Otake, Koji; Ogata, Yasuhiro; Nakagawa, Kazuko

doi:10.1515/cclm-2015-0331

Cited by 1 publication

(1 citation statement)

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“…Jinnouchi et al (2015) reported that GGT1 rs4820599 genotype was an independent risk factor for diabetic retinopathy and OS influences the process. Based on previous studies, the polymorphisms of the GGT1 and HNF1A genes could influence the level of GGT expression (Middelberg et al, 2012;Morita et al, 2015;Yuan et al, 2008). Plasma GGT levels are probably caused by genetics, as indicated by the observed genetic covariance in a twin study (Loomba et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Family-based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome

Qin

Tian

et al. 2018

Reproductive BioMedicine Online

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Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disease. Previous studies indicate that genes GGT1 and HNF1A may contribute to the abnormal glucose metabolism and altered lipid profile that are important clinical features of PCOS. In the current study, the correlation between polymorphisms in the GGT1 and HNF1A genes and PCOS was explored. A total of 310 family trios were studied and the transmission disequilibrium test (TDT) was used to assess the linkage between PCOS and three single-nucleotide polymorphisms (SNP) (rs4820599 of GGT1, rs7305618 and rs2393791 of HNF1A). No deviations from HWE were detected. None of the three SNP markers showed significant transmission disequilibrium in PCOS family trios (rs4820599: GGT1 gene, χ = 1.067; rs7305618: HNF1A gene, χ = 0.013; rs2393791: HNF1A gene, χ = 0.031). In conclusion, no significant evidence supported a relationship between genes GGT1 and HNF1A and PCOS in the current family trios.

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