A General Practitioner’s Guide to Hematopoietic Stem-cell Transplantation

Bazinet, Alexandre; Popradi, Gizelle

doi:10.3747/co.26.5033

Cited by 112 publications

(77 citation statements)

References 44 publications

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“…On the other hand, according to the source, HSCs can be obtained from bone marrow, peripheral blood, or CB. Although HSCs were first harvested from bone marrow, nowadays and due to the development of mobilization procedures, such as the use of granulocyte colony-stimulating factor (G-CSF), peripheral blood is the main source of precursors [ 108 , 109 ].…”

Section: The Role Of Nk Cells In Autologous Hematopoietic Stem Celmentioning

confidence: 99%

Human NK Cells in Autologous Hematopoietic Stem Cell Transplantation for Cancer Treatment

Orrantia

Terrén

Astarloa-Pando

et al. 2021

Cancers

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Natural killer (NK) cells are phenotypically and functionally diverse lymphocytes with the ability to recognize and kill malignant cells without prior sensitization, and therefore, they have a relevant role in tumor immunosurveillance. NK cells constitute the main lymphocyte subset in peripheral blood in the first week after hematopoietic stem cell transplantation (HSCT). Although the role that NK cells play in allogenic HSCT settings has been documented for years, their significance and beneficial effects associated with the outcome after autologous HSCT are less recognized. In this review, we have summarized fundamental aspects of NK cell biology, such as, NK cell subset diversity, their effector functions, and differentiation. Moreover, we have reviewed the factors that affect autologous HSCT outcome, with particular attention to the role played by NK cells and their receptor repertoire in this regard.

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Section: The Role Of Nk Cells In Autologous Hematopoietic Stem Celmentioning

confidence: 99%

Human NK Cells in Autologous Hematopoietic Stem Cell Transplantation for Cancer Treatment

Orrantia

Terrén

Astarloa-Pando

et al. 2021

Cancers

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“…Harvesting and printing the cells in the same sitting could only be done with knowledge of specific markers for MSC, which we lack at present. This is feasible for other cell types with, such as for example the hematopoietic stem cells, which are currently used without manipulation in cancer patients following whole body irradiation ( Bazinet and Popradi, 2019 ). For MSCs however, at present there is a lack of robust techniques for cell isolation and purification that do not affect MSCs biology and then cell preservation strategies.…”

Section: Post-printingmentioning

confidence: 99%

Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells

Belk

Tellisi

Macdonald

et al. 2020

Front. Bioeng. Biotechnol.

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Three-dimensional (3D) bioprinting has demonstrated great potential for the fabrication of biomimetic human tissues and complex graft materials. This technology utilizes bioinks composed of cellular elements placed within a biomaterial. Mesenchymal stromal cells (MSCs) are an attractive option for cell selection in 3D bioprinting. MSCs can be isolated from a variety of tissues, can pose vast proliferative capacity and can differentiate to multiple committed cell types. Despite their promising properties, the use of MSCs has been associated with several drawbacks. These concerns are related to the ex vivo manipulation throughout the process of 3D bioprinting. The herein manuscript aims to present the current evidence surrounding these events and propose ways to minimize the risks to the patients following widespread expansion of 3D bioprinting in the medical field.

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“…Hematopoietic cell transplant (HCT) is utilized to treat a variety of malignant and non-malignant disorders [1]. High doses of chemotherapy often in combination with irradiation are used to ablate hematopoietic stem cells as well as cells of the immune system which mediate rejection.…”

Section: Introductionmentioning

confidence: 99%

Parent proxy assessment of sibling quality of life following pediatric hematopoietic cell transplantation

Buchbinder

Patel

Casillas

et al. 2019

Health Qual Life Outcomes

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BackgroundWhen a child undergoes hematopoietic cell transplantation (HCT), the impact extends to the entire family, including siblings. Assessment of the quality of life (QoL) of siblings is challenged by their general lack of availability for regular assessment by clinical providers. Thus, the use of parent proxy reporting may be useful. Our aim was to describe the QoL of siblings of HCT survivors, as reported by their parents, as well as to identify parent and family factors associated with lower sibling QoL.MethodsA cross-sectional study was utilized to assess parent-reported QoL of the HCT recipient’s sibling (Short Form (SF)-10 Health Survey for Children and the Pediatric Symptom Checklist (PSC)-17). Parent QoL was assessed using the SF-12. Multivariable linear regression was used to explore hypothesized predictors of sibling QoL, including parent QoL, family impact/function (Impact on Family Scale, Family Adaptability and Cohesion Evaluation Scales, IV, and a question asking about financial problems) while adjusting for demographic and HCT characteristics.ResultsNinety-seven siblings (55% males) with a mean age of 12 years (standard deviation [SD] 4 years) were assessed, representing HCT survivors, who were an average of 5 years (SD 4 years) post-HCT. Neither sibling psychosocial (mean 49.84, SD 10.70, p = 0.87) nor physical health scores (mean 51.54, SD 8.42, p = 0.08) differed from norms. Parent proxies reported behavioral/emotional problems (PSC-17 total score > 15) in 24% of siblings. While parental ratings of their own physical health (SF-12 were higher than norms (mean 53.04, SD 8.17, p = 0.0005), mental health scores were lower (mean 45.48, SD 10.45, p < 0.0001). In multivariable analysis, lower parent emotional functioning and adverse family function were associated with lower sibling QoL, as reported by parents.ConclusionsWhile proxy-reported QoL of siblings did not differ significantly from normative data, both parent QoL and family function were associated with sibling QoL. Future research is needed to understand how siblings themselves perceive their QoL following HCT.

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A General Practitioner’s Guide to Hematopoietic Stem-cell Transplantation

Cited by 112 publications

References 44 publications

Human NK Cells in Autologous Hematopoietic Stem Cell Transplantation for Cancer Treatment

Human NK Cells in Autologous Hematopoietic Stem Cell Transplantation for Cancer Treatment

Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells

Parent proxy assessment of sibling quality of life following pediatric hematopoietic cell transplantation

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