A general strategy for the synthesis of upconversion rare earth fluoride nanocrystals via a novel OA/ionic liquid two-phase system

Meng, He; Huang, Peng; Zhang, Chunlei; Chen, Feng; Wang, Can; Ma, Jiebing; He, Rong; Cui, Daxiang

doi:10.1039/c1cc12886h

Cited by 49 publications

(36 citation statements)

References 27 publications

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“…The synthetic principle and protocol of LaF 3 :Yb,Er UCNPs with different components (various combinations of host materials, sensitizers, and activators) and solubilities (water-solubility and nonpolar solvents-solubility) were reported in our previous works 26, 27. and other groups achievements28, 29 Transmission electron microscope (TEM) and X-ray powder diffraction (XRD) were performed to investigate the morphology and structure of UNCPs.…”

Section: Methodsmentioning

confidence: 99%

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF₃:Yb,Er in Early Development of Zebrafish Embryos

Wang¹,

Ma²,

Meng³

et al. 2013

Theranostics

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This study reports the effects of upconversion nanoparticles (UCNPs) LaF3:Yb,Er on zebrafish, with the aim of investigating UCNPs toxicity. LaF3:Yb,Er were prepared by an oleic acid/ionic liquid two-phase system, and characterized by transmission electron microscope and X-ray powder diffraction. 140 zebrafish embryos were divided into six test groups and one control group, and respectively were injected into 5, 25, 50, 100, 200, 400 μg/mL LaF3:Yb,Er@SiO2 solution, and respectively were raised for 5 days. Each experiment was repeated ten times. Results showed that water-soluble LaF3:Yb,Er were successfully prepared, and did not exhibit obvious toxicity to zebrafish embryos under 100 μg/mL, but exhibited chronic toxicities 200 μg/mL in vivo, resulting in malformations and delayed hatching rate and embryonic and larval development. The excretion channels of LaF3:Yb,Er in adult zebrafish were mainly found in the intestine after being injected evenly for 24 h. In conclusion, the exploration of LaF3:Yb,Er for in vivo applications in animals and humans must consider UCNPs biocompatibility.

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Section: Methodsmentioning

confidence: 99%

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF₃:Yb,Er in Early Development of Zebrafish Embryos

Wang¹,

Ma²,

Meng³

et al. 2013

Theranostics

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“…Finally, the Bif-ILEs stabilized the nanostructures from aggregating. Daxiang Cui et al reported a general strategy to synthesize highly uniform and monodisperse rare earth fluoride nanocrystals through a novel OA/ionic liquid two-phase system [56][57][58]. They adopt the notion of liquid-liquid two-phase reaction and devise a novel oleic acid (OA)/1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF 4 ) two-phase system, which combines the merits of thermal decomposition (size and morphology control) and IL-based strategy (mild conditions, user-friendly reagents, and direct water solubility).…”

Section: Ionic Liquid Microemulsionmentioning

confidence: 99%

Ionic Liquid-Assisted Hydrothermal Synthesis of Rare Earth Luminescence Materials

Song

Deng

Chen

et al. 2016

Green Chemistry and Sustainable Technology

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The shape control of nano-and microcrystals has received considerable attention because the morphology, dimensionality, and size of materials are well known to have great effects on their physical and chemical properties, as well as on their applications in optoelectronic devices. Ionic liquids were found to be very advantageous in synthetic nanochemistry, especially as templates and capping agents. Their particular phase behavior and unique physicochemical properties, including complex solvation interactions with organic and inorganic compounds, can provide various growth pathways for nanocrystals with novel morphologies and properties. This chapter gives an overview of existing ionic liquid-assisted hydrothermal method for the synthesis of rare earth luminescence materials. Particular attention is given to synthesis mechanism and the role of ionic liquids in the formation of specific morphology, as well as the effect of morphology on the luminescent properties.

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“…Consequently, our group have adopted the notion of liquid-liquid twophase approach (the advantage of thermal decomposition method) and ILs as fluorine source (the advantage of IL-based strategy) and create a novel IL-OA dual phase method ( Fig. 2), by which hydrophilic and hydrophobic Ln-dopedNaYF 4 ,NaGdF 4 ,NaYbF 4 ,LaF 3 could be selectively synthesized in a one-pot step [33][34][35][36][37]. We are confident that other kinds of UCNPs with excellent morphology and UC emissions can be gained by this method as well.…”

Section: Advances Of Preparation Of Ucnpsmentioning

confidence: 99%

Advances of Upconversion Nanoparticles for Molecular Imaging

Zhou¹,

Ni²,

He³

2013

Nano BioMed ENG

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Molecular imaging is developing fast towards multi-modality and simultaneous therapy. For molecular imaging, upconversion nanoparticles (UCNPs), especially lanthanide-doped nanocrystals own obvious advantages such as low toxicity, large Stokes shifts, high resistance to photo-bleaching and photochemical degradation. Moreover, near infrared (NIR) excitation contributes to the auto-fluorescence minimization, a larger penetrating depth, and less harmfulness to cells compared with traditional ultraviolet (UV) excitation. On the other hand, the composites of UCNPs with biological target molecules exert superior performance, broadening their biological application scope from multi-modality imaging, to simultaneous drug delivery and targeted therapy. Herein, we review main advances of UCNPs applied to tumor multi-modality imaging and simultaneous therapy over the past few years, explore their application prospects, and discuss the concepts, issues, approaches, and challenges, with the aim of improving the application of UCNPs in biomedical imaging and therapy in near future.

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A general strategy for the synthesis of upconversion rare earth fluoride nanocrystals via a novel OA/ionic liquid two-phase system

Abstract: Herein we report a general strategy to synthesize highly uniform and monodisperse rare earth fluoride nanocrystals through a novel OA/ionic liquid two-phase system, while water-soluble hexagonal NaREF(4) nanocrystals are obtained by adding n-octanol.

Cited by 49 publications

References 27 publications

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF₃:Yb,Er in Early Development of Zebrafish Embryos

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF₃:Yb,Er in Early Development of Zebrafish Embryos

Ionic Liquid-Assisted Hydrothermal Synthesis of Rare Earth Luminescence Materials

Advances of Upconversion Nanoparticles for Molecular Imaging

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A general strategy for the synthesis of upconversion rare earth fluoride nanocrystals via a novel OA/ionic liquid two-phase system

Abstract: Herein we report a general strategy to synthesize highly uniform and monodisperse rare earth fluoride nanocrystals through a novel OA/ionic liquid two-phase system, while water-soluble hexagonal NaREF(4) nanocrystals are obtained by adding n-octanol.

Cited by 49 publications

References 27 publications

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos

Ionic Liquid-Assisted Hydrothermal Synthesis of Rare Earth Luminescence Materials

Advances of Upconversion Nanoparticles for Molecular Imaging

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Resources

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Toxicity Assessments of Near-infrared Upconversion Luminescent LaF₃:Yb,Er in Early Development of Zebrafish Embryos

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF₃:Yb,Er in Early Development of Zebrafish Embryos