Using the Lax operator formalism, we construct a family of pairwise commuting operators such that the Macdonald symmetric functions of infinitely many variables x 1 , x 2 , . . . and of two parameters q, t are their eigenfunctions. We express our operators in terms of the Hall-Littlewood symmetric functions of the variables x 1 , x 2 , . . . and of the parameter t corresponding to the partitions with one part only. Our expression is based on the notion of Baker-Akhiezer function.