2023
DOI: 10.21203/rs.3.rs-3171930/v1
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A genome-wide association study identifies a locus associated with knee extension strength in older people

Abstract: Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3,452 Japanese aged 60 years or older from two independent cohorts. We identified a significant association in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10− 8). TACC2, encoding a cytoskeleton-related prot… Show more

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