A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

Krivoruchko, Alexander; Surov, Alexander; Skokova, A. V.; Kanibolotskaya, Anastasiya; Saprikina, Tatiana; Kukharuk, M.; Yatsyk, Olesya

doi:10.3390/genes13081337

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…Additionally, this conclusion confirms the impossibility of clustering the selected group of animals based on data on complex genotypes. A similar pattern with respect to genotypes by loci of known meat productivity genes was observed in our previous studies in sheep of the Jalgin merino breed [33]. This indicates a certain stability in the influence of known productivity genes created as a result of the development of the breed.…”

Section: Discussionsupporting

confidence: 87%

Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K

Krivoruchko

Likhovid

Kanibolotskaya

et al. 2023

Genes

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In a group of Karachaevsky rams, a genome-wide associations analysis of single nucleotide polymorphisms (SNPs) with live parameters of meat production was performed. We used for genotyping the Ovine Infinium HD BeadChip 600 K, which consists of points to detection of 606,000 polymorphisms. A total of 12 SNPs was found to be significantly associated with live meat quality parameters of the corpus and legs and ultrasonic traits. In this case, 11 candidate genes were described, the polymorphic variants of which can change in sheep body parameters. We found SNPs in the exons, introns, and other regions of some genes and transcripts: CLVS1, EVC2, KIF13B, ENSOART00000000511.1, KCNH5, NEDD4, LUZP2, MREG, KRT20, KRT23 and FZD6. The described genes involved in the metabolic pathways of cell differentiation, proliferation and apoptosis are connected with the regulation of the gastrointestinal, immune and nervous systems. In known productivity genes (MSTN, MEF2B, FABP4, etc.), loci were not found to be a significant presence of influence on the meat productivity of the Karachaevsky sheep phenotypes. Our study confirms the possible involvement of the identified candidate genes in the formation of the phenotypes of productivity traits in sheep and indicates the need for new research into candidate genes structure in point to detect their polymorphisms.

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Section: Discussionsupporting

confidence: 87%

Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K

Krivoruchko

Likhovid

Kanibolotskaya

et al. 2023

Genes

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“…This is the current molecular strategy to address polygenic features of HD with strong environmental components. Nevertheless, it has not been possible to obtain a feasible molecular diagnosis for HD, despite the success of this methodology in similar genetic traits, such as meat and milk production [ 91 , 92 ]. The research in this field of genetic diagnosis in canine HD remains essential, enabling the introduction of genomic selection.…”

Section: Main Textmentioning

confidence: 99%

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Tomé,

Alves-Pimenta,

Sargo

et al. 2023

BMC Vet Res

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Human and veterinary medicine have historically presented many medical areas of potential synergy and convergence. Mechanical osteoarthritis (MOA) is characterized by a gradual complex imbalance between cartilage production, loss, and derangement. Any joint instability that results in an abnormal overload of the joint surface can trigger MOA. As MOA has a prevailing mechanical aetiology, treatment effectiveness can only be accomplished if altered joint mechanics and mechanosensitive pathways are normalized and restored. Otherwise, the inflammatory cascade of osteoarthritis will be initiated, and the changes may become irreversible. The management of the disease using non-steroidal anti-inflammatory drugs, analgesics, physical therapy, diet changes, or nutraceuticals is conservative and less effective. MOA is a determinant factor for the development of hip dysplasia in both humans and dogs. Hip dysplasia is a hereditary disease with a high incidence and, therefore, of great clinical importance due to the associated discomfort and significant functional limitations. Furthermore, on account of analogous human and canine hip dysplasia disease and under the One Medicine concept, unifying veterinary and human research could improve the well-being and health of both species, increasing the acknowledgement of shared diseases. Great success has been accomplished in humans regarding preventive conservative management of hip dysplasia and following One Medicine concept, similar measures would benefit dogs. Moreover, animal models have long been used to better understand the different diseases’ mechanisms. Current research in animal models was addressed and the role of rabbit models in pathophysiologic studies and of the dog as a spontaneous animal model were highlighted, denoting the inexistence of rabbit functional models to investigate therapeutic approaches in hip MOA.

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Genome-Wide Association Study for Meat Quality Traits in a Multi-Breed Pig Population

Kamiński,

Tarczyński,

Oleński

et al. 2024

Annals of Animal Science

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This study aimed at identifying genomic regions that affect nine pork quality traits in purebred and crossbred fatteners. A total of 259 fatteners represented by six purebreds/crosses were genotyped for 45556 SNP markers by Illumina Porcine SNP60 BeadChip. The following traits were recorded: glycogen potential (GP), glycogen content (GC), lactate content (LC), pH35, pH24, pH48, drip loss after 48 hours (DL48), color lightness (L *) and lean meat content (LMC). Multi-Locus Mixed Model methodology was applied to find associations between SNP markers and recorded traits. Several SNPs were found to be significantly associated with some pork quality traits: four SNPs (located on SSC7, SSC10 and SSC14) with GP, three SNPs (SSC10, SSC14) with GC, one SNP (SSC15) with DL48 and one SNP with pH48. Genetic variation explained by significant SNPs ranged from 7.6% to 9.1%. Moreover, some genes (e.g. CAPN10, ALDH5A1, PASK, SNITA1 and MYH7B) located in the close vicinity to significant markers are proposed to be candidate genes explaining the genetic background of the traits studied.

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A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

Cited by 5 publications

References 41 publications

Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K

Genome-Wide Search for Associations with Meat Production Parameters in Karachaevsky Sheep Breed Using the Illumina BeadChip 600 K

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Genome-Wide Association Study for Meat Quality Traits in a Multi-Breed Pig Population

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