A Giant Simple Liver Cyst That Caused Increases in Serum CA 19-9 and CA 15-3 Levels

Abstract

Simple cysts (SCs) of the liver are not associated with the biliary malformations in intrahepatic bile duct biliary. Seen in 0.1% to 7% of adult population, biliary malformations are more common in women. The levels of glycoprotein-like tumor markers (carbohydrate antigen (CA) 19-9) in the cysts and serum could be high. Although studies regarding CA 19-9 exist, sufficient data on cancer antigen (CA) 15-3 are not available. This case is about a 76-year-old woman who complained of painless intra-abdominal mass. The patient with a giant simple cyst extending from the gallbladder to the pelvis had preoparative CA 19-9 and CA 15-3 serum levels of 87.3 IU/L and 37 IU/L respectively. It was observed that CA 19-9 levels had decreased to 36 IU/L and CA 15-3 to 28.1 IU/L in blood samples taken in the third month after the surgery. There is a need for comprehensive studies to investigate the relationship between the size of the cyst and biomarkers (including markers such as CA 15-3) in the assesment of liver SC.

Congenital hepatic cyst with intracystic hemorrhage

“…In Case 1 in the present study, serum CA19-9 was significantly elevated (CA19-9 in the cystic fluid: NA), and in Case 2, serum CA19-9 was not high (CA19-9 in the cystic fluid: NA). Dinc et al [8] reported 1 case of a huge hepatic cyst with elevated serum CA19-9; the authors believed that the elevated CA19-9 may have been related to compression of the surrounding organs by the huge hepatic cyst and excessive secretion by the epithelial tissue in the thickened cystic wall. Horsmans determined CA19-9 levels in the serum and the cystic fluid in 1 case of cystadenoma and 1 case of cystadenocarcinoma and found that both serum CA19-9 and CA19-9 in the cystic fluid were elevated in cystadenoma and cystadenocarcinoma, whereas only CA19-9 in the cystic fluid was elevated in a congenital hepatic cyst.…”

Relación entre el quiste hepático simple múltiple y la litiasis vesicular

“…La ecografía es el método de elección para el diagnóstico de estos quistes (8) . La tomografía y resonancia magnética pueden ser útiles para diferenciarlos de otras anormalidades (12) . Los criterios ultrasonográficos para el diagnóstico de quiste hepático simple son: imagen anecoica (es decir, cavidad llena de fluido), sin tabiques, bordes lisos afilados, fuertes ecos de la pared posterior (lo que indica una interfaz de fluido/tejido bien definido), esférica o de forma ovalada y una acentuación relativa de los ecos más allá del quiste en comparación con ecos en una profundidad similar transmitida a través de tejido hepático normal adyacente (13) .…”