A glass half-full: defining ventilator-associated pneumonia in the neonatal intensive care unit

Whitesel, Emily; Gupta, Munish

doi:10.1038/s41390-020-0884-8

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…The aim was to obtain a more general and objective criterion of complications associated with the ventilator to detect both infectious and non-infectious complications. These VAE definitions have the necessary validity and reliability to be used in external quality assessments and benchmarking [ 69 ]. However, VAP definitions, despite the difficulties described, have been shown to be useful as a measure of improving the internal quality of centers on an individual level [ 70 ].…”

Section: Ventilator-associate Pneumonia (Vap)mentioning

confidence: 99%

Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period

García-Muñoz Rodrigo,

Urquía Martí,

Siguero Onrubia

et al. 2024

Pathogens

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The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from, or even before, birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in newborns and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neonatal patients undergoing mechanical ventilation. In this article, the current evidence on the composition of the lung microbiota in newborns will be reviewed, as well as the risks that an altered microbiota can impose on premature newborns. Although advances in neonatal intensive care units have significantly improved the survival rate of preterm infants, the diagnosis and treatment of ventilator-associated pneumonia has not progressed in recent decades. Avoiding dysbiosis caused by inappropriate use of antibiotics around birth, as well as avoiding intubation of patients or promoting early removal of endotracheal tubes, are among the most important preventive measures for ventilator-associated pneumonia. The potential benefit of probiotics and prebiotics in preventing infectious, allergic or metabolic complications in the short or long term is not clearly established and constitutes a very important field of research in perinatal medicine.

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Section: Ventilator-associate Pneumonia (Vap)mentioning

confidence: 99%

Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period

García-Muñoz Rodrigo,

Urquía Martí,

Siguero Onrubia

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

Lung Microbiota and Ventilator‐Associated Pneumonia in the Neonatal Period

García-Muñoz Rodrigo,

Urquía Martí,

Siguero Onrubia

et al. 2024

Preprint

View full text Add to dashboard Cite

The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from or even before birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in the newborn and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neona-tal patients undergoing mechanical ventilation. In this article, the current evidence on the compo-sition of the lung microbiota in the newborn will be reviewed, as well as its role in the develop-ment of bacterial infections in mechanically ventilated neonates. Although advances in many as-pects of the neonatal intensive care unit care have significantly improved the survival of preterm infants, the diagnosis and treatment of ventilator-associated pneumonia has not progressed in recent decades. Avoiding dysbiosis caused by inappropriate use of antibiotics around birth, as well as avoiding intubation of patients or promoting early removal of endotracheal tubes are among the most important preventive measures for ventilator-associated pneumonia. The use of probiotics and prebiotics to prevent infectious, allergic or metabolic complications in the short or long term constitutes a very important field of research in perinatal medicine.

show abstract

A glass half-full: defining ventilator-associated pneumonia in the neonatal intensive care unit

Cited by 2 publications

References 21 publications

Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period

Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period

Lung Microbiota and Ventilator‐Associated Pneumonia in the Neonatal Period

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