A glimpse on biological activities of tellurium compounds

Cunha, Rodrigo L. O. R.; Gouvêa, Iuri E.; Juliano, Luiz

doi:10.1590/s0001-37652009000300006

Cited by 166 publications

(121 citation statements)

References 86 publications

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“…These observations have encouraged further studies of tellurium- 3 (22) based compounds as inhibitors of this class of enzyme. In this context, Cunha and co-workers have presented series of organotellurium compounds that show irreversible inhibitory activity greater than AS-101 against Cathepsin B as well as being irreversible inhibitors against Cathepsins K, L and S [31,32].…”

Section: Decane (1) (3e)-2-chloro-3-(chloromethylidene)-2-(4-methoxymentioning

confidence: 99%

“…The inhibition occurs due to the formation of a Te(IV)-SG covalent bond between the electrophilic tellurium(IV) centre and the nucleophilic thiol group of the catalytic cysteine via the loss of a leaving group bound to the tellurium atom [31,32,47,48]. According to previous work [47,48], to create an environment to satisfy the covalent complex hypothesis, the telluriumbound halide, considered the best leaving group in each of 1-4, was removed giving the corresponding cations 1ꞌ, 2ꞌ, 3ꞌ and 4ꞌ, respectively and these were used to simulate the formation of the Cathepsin-telluroxetane complexes in the enzymes listed in Table 3.…”

Section: Enzymementioning

confidence: 99%

“…7: Second-order rate constant values (10 3 M -1 s -1 ) for the inhibition of the studies Cathepsins (Cat.) by the telluroxetanes 1-3 [31,32].…”

Section: Subsitementioning

confidence: 99%

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Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Caracelli

Maganhi

Cardoso

et al. 2017

Zeitschrift Für Kristallographie - Crystalline Materials

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Abstract. The molecular structures of the halotelluroxetanes pMeOC6H4Te(X)[C(=C(H)Xꞌ)C(CH2)nO], X = Xꞌ = Cl and n = 6 (1) and X = Cl, Xꞌ = Br and n = 5 (4), show similar binuclear aggregates sustained by { … Te-O}2 cores comprising covalent Te-O and secondary Te⋯O interactions. The resulting C2ClO2(lone-pair) sets define pseudo-octahedral geometries. In each structure, C-X⋯(arene) interactions lead to supramolecular layers. Literature studies have shown these and related compounds (i.e. 2: X = Xꞌ = Cl and n = 5; 3: X = Xꞌ = Br and n = 5) to inhibit Cathepsins B, K, L and S to varying extents. Molecular docking calculations have been conducted on ligands (i.e. cations derived by removal of the telluriumbound X atoms) 1ꞌ-3ꞌ (note 3ꞌ = 4ꞌ) enabling correlations between affinity for sub-sites and inhibition. The common feature of all docked complexes was the formation of a Te-S covalent bond with cysteine residues, the relative stability of the ligands with an E-configuration and the formation of a C-O … π interaction with the phenyl ring; for 1ꞌ the Te-S covalent bond was weak, a result correlating with its low inhibition profile. At the next level differences are apparent, especially with respect to the interactions formed by the organic-ligand-bound halides.

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Section: Decane (1) (3e)-2-chloro-3-(chloromethylidene)-2-(4-methoxymentioning

confidence: 99%

Section: Enzymementioning

confidence: 99%

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Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Caracelli

Maganhi

Cardoso

et al. 2017

Zeitschrift Für Kristallographie - Crystalline Materials

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“…Organotellurium (OT) compounds have been pointed out as promising and useful alternatives for numerous synthetic operations in organic synthesis, as seen in the increase of reports on OT chemistry appearing in the literature [1,2]. In the last few decades, evidence has been accumulating that OT molecules are promising pharmacological agents.…”

mentioning

confidence: 99%

Diphenyl Ditelluride‐Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition

Jorge

Oliveira

Filippi-Chiela

et al. 2014

Basic Clin Pharma Tox

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The diphenyl ditelluride (DPDT) is a prototype for the development of new biologically active molecules. In previous studies, DPDT showed an elevated cytotoxicity in Chinese hamster fibroblast (V79) cells but the mechanisms for reduction of cell viability still remain unknown. DPDT showed mutagenic properties by induction of frameshift mutations in bacterium Salmonella typhimurium and yeast Saccharomyces cerevisiae. This organotelluride also induced DNA strand breaks in V79 cells. In this work, we investigated the mechanism of DPDT cytotoxicity by evaluating the effects of this compound on cell cycle progression, apoptosis induction and topoisomerase I inhibition. Significant decrease of V79 cell viability after DPDT treatment was revealed by MTT assay. Morphological analysis showed induction of apoptosis and necrosis by DPDT in V79 cells. An increase of caspase 3/7 activity confirmed apoptosis induction. The cell cycle analysis showed an increase in the percentage of V79 cells in S phase and sub-G1 phase. The yeast strain deficient in topoisomerase I (Topo I) showed higher tolerance to DPDT compared with the isogenic wild-type strain, suggesting that the interaction with this enzyme could be involved in DPDT toxicity. The sensitivity to DPDT found in top3Δ strain indicates that yeast topoisomerase 3 (Top3p) could participate in the repair of DNA lesions induced by the DPDT. We also demonstrated that DPDT inhibits human DNA topoisomerase I (Topo I) activity by DNA relaxation assay. Therefore, our results suggest that the DPDT-induced cell cycle arrest and reduction in cell viability could be attributed to interaction with topoisomerase I enzyme.

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“…24 In addition, some diaryl tellurides were found to inhibit the growth of cancer cells (e.g., human MCF-7 breast cancer, HT-29 colon cancer, Colo320 colon cancer).…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Potentials of Tellurium Nanowires in BALB/3T3 Fibroblast Cells

Mahto¹,

Kim²,

Rhee³

2011

Bulletin of the Korean Chemical Society

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We have investigated the cytotoxic potential of tellurium (Te) nanowires in BALB/3T3 fibroblast cells. Te nanowires were synthesized through an aqueous phase surfactant assisted method. Toxicological experiments, such as analysis of morphological changes, MTT assay, DAPI staining, and estimation of intracellular reactive oxygen species, were carried out to reveal the cytotoxic effects of Te nanowires. Te nanowires were found to be cytotoxic at all concentrations tested, in a dose-dependent manner. The UV/Vis spectra of Te nanowires suspended in a culture medium showed drastic changes and disappearance of two broad absorption peaks. The physicochemical properties such as, surface charge, size, and shape of Te nanowires were found to be altered during exposure of cells, due to the instability and agglomeration of nanowires in the culture medium. These results suggest that the chemical components of the DMEM medium significantly affect the stability of Te nanowires. In addition, TEM images revealed that necrosis was the basic pattern of cell death, which might stem from the formation of toxic moieties of tellurium, released from nanowire structures, in the bioenvironment. These observations thus suggest that Te nanomaterials may pose potential risks to environmental and human health.

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A glimpse on biological activities of tellurium compounds

Cited by 166 publications

References 86 publications

Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Crystallographic and docking (Cathepsins B, K, L and S) studies on bioactive halotelluroxetanes

Diphenyl Ditelluride‐Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition

Cytotoxic Potentials of Tellurium Nanowires in BALB/3T3 Fibroblast Cells

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