A global analysis of conservative and non-conservative mutations in SARS-CoV-2 detected in the first year of the COVID-19 world-wide diffusion

Balasco, Nicole; Damaggio, Gianluca; Esposito, Luciana; Villani, Flavia; Berisio, Rita; Colonna, Vincenza; Vitagliano, Luigi

doi:10.1038/s41598-021-04147-1

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…2B ), suggesting that newly arising variants (e.g., Q, M, and R) have a low genetic barrier toward the codon change at this position. This is in agreement with a prior global mutational analysis study of SARS-CoV-2, which demonstrated that SNAMs are present at much higher frequencies ( 29 ). However, some exceptions on the basis of selection pressure exist, for instance, certain L452 mutations despite having a lower genetic barrier (e.g., P and V) showed very low global frequency ( Fig.…”

Section: Resultssupporting

confidence: 92%

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Tan

Toyoda

Ode

et al. 2022

J Virol

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Section: Resultssupporting

confidence: 92%

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Tan

Toyoda

Ode

et al. 2022

J Virol

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“…The most mutation is D614G, namely 16 samples. This mutation is classi ed as a non-conservative type of amino acid change because it has a PAM value of 11, as well as different properties and characteristics (Table 5) (Balasco et al 2021).…”

Section: Resultsmentioning

confidence: 99%

Study on Sequence Mutation and Molecular Dynamics Simulation of D614G SARS-CoV-2 Spike Protein in Indonesia

Rahmi

Utomo

Susanti

2023

Preprint

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Amino acid mutations in the D614G spike protein of SARS-CoV-2 need to be studied more deeply for their influence on the pathogenesis of the virus. The purpose of this research was to analyze 1) the variation and kinship of the SARS-CoV-2 spike protein gene; 2) the effect of D614G spike protein mutation on ACE2 receptor binding and the molecular dynamics simulation. The nucleotide sequence of SARS-CoV-2 virus isolate was downloaded from GISAID and NCBI. Classification of SARS-CoV-2 clades and construction of the phylogenetic tree using MEGA-program. Molecular dynamics simulation was demonstrated with GROMACS to compare the stability of D614 and G614 S proteins. The result of this research showed that the most common GH clade SARS-CoV-2 virus isolates were be discovered in Indonesia, and the percentage of isolates with the D614G mutation reached 97% in Indonesia. The clade with the D614G mutation made the SARS-CoV-2 virus more varied with new mutations and increased human-to-human transmision. In this study, an increase in infectivity or spread of the SARS-CoV-2 D614G virus most likely resulted from an increase in the strength of the S protein and a slight change in RBD conformation seen from the molecular interactions around the mutation area and the RMSF value (0.3144 nm for D614G, and 0.3818 nm for D614). This is likely to be the cause of the massive spread of variants belonging to VOC and VBM, where all these variants have the D614G mutation.

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“…Speech recognition systems represent a trend that became more entrenched during the COVID-19 pandemic (Balasco et al. 2021 ; Mumtaz et al. 2021 ).…”

Section: Securitymentioning

confidence: 99%

Biometrics for Industry 4.0: a survey of recent applications

Cascone

Nappi

2023

J Ambient Intell Human Comput

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The Fourth Industrial Revolution, also known as Industry 4.0, represents the rise of digital industrial technology that is propagating at an exponential rate compared to the previous three revolutions. Interoperability is a basis of production, where there is a continuous exchange of information between machines and production units that act autonomously and intelligently. Workers play a central role in making autonomous decisions and using advanced technological tools. It may involve using measures that distinguish individuals, and their behaviours and reactions. Increasing the level of security, allowing only authorized personnel access to designated areas, and promoting worker welfare can have a positive impact on the entire assembly line. Thus, capturing biometric information, with or without individuals’ knowledge, could allow identity verification and monitoring of of their emotional and cognitive states during the daily actions of work life. From the study of the literature, we outline three macro categories in which the principles of Industry 4.0 are merged and the functionalities of biometric systems are exploited: security, health monitoring, and quality work life analysis. In this review, we present an overview of all biometric features used in the context of Industry 4.0 with a focus on their advantages, limitations, and practical use. Attention is also paid to future research directions for which new answers are being explored.

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A global analysis of conservative and non-conservative mutations in SARS-CoV-2 detected in the first year of the COVID-19 world-wide diffusion

Cited by 6 publications

References 26 publications

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Study on Sequence Mutation and Molecular Dynamics Simulation of D614G SARS-CoV-2 Spike Protein in Indonesia

Biometrics for Industry 4.0: a survey of recent applications

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