A Global, Multi-Disciplinary, Multi-Sectorial Initiative to Combat Leptospirosis: Global Leptospirosis Environmental Action Network (GLEAN)

Durski, Kara; Jancloes, Michel; Chowdhary, Tej; Bertherat, Eric

doi:10.3390/ijerph110606000

Cited by 28 publications

(28 citation statements)

References 13 publications

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“…However, little information is available as to the broader population-level impacts of human health benefits of livestock vaccination schemes, and this remains an important gap that needs to be addressed [64]. …”

Section: Designing One Health Interventions: the Example Of Livestockmentioning

confidence: 99%

One Health contributions towards more effective and equitable approaches to health in low- and middle-income countries

Cleaveland

Sharp

Abela-Ridder

et al. 2017

Phil. Trans. R. Soc. B

160

162

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Emerging zoonoses with pandemic potential are a stated priority for the global health security agenda, but endemic zoonoses also have a major societal impact in low-resource settings. Although many endemic zoonoses can be treated, timely diagnosis and appropriate clinical management of human cases is often challenging. Preventive ‘One Health’ interventions, e.g. interventions in animal populations that generate human health benefits, may provide a useful approach to overcoming some of these challenges. Effective strategies, such as animal vaccination, already exist for the prevention, control and elimination of many endemic zoonoses, including rabies, and several livestock zoonoses (e.g. brucellosis, leptospirosis, Q fever) that are important causes of human febrile illness and livestock productivity losses in low- and middle-income countries. We make the case that, for these diseases, One Health interventions have the potential to be more effective and generate more equitable benefits for human health and livelihoods, particularly in rural areas, than approaches that rely exclusively on treatment of human cases. We hypothesize that applying One Health interventions to tackle these health challenges will help to build trust, community engagement and cross-sectoral collaboration, which will in turn strengthen the capacity of fragile health systems to respond to the threat of emerging zoonoses and other future health challenges. One Health interventions thus have the potential to align the ongoing needs of disadvantaged communities with the concerns of the broader global community, providing a pragmatic and equitable approach to meeting the global goals for sustainable development and supporting the global health security agenda.This article is part of the themed issue ‘One Health for a changing world: zoonoses, ecosystems and human well-being’.

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Section: Designing One Health Interventions: the Example Of Livestockmentioning

confidence: 99%

One Health contributions towards more effective and equitable approaches to health in low- and middle-income countries

Cleaveland

Sharp

Abela-Ridder

et al. 2017

Phil. Trans. R. Soc. B

160

162

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“…(DOCX) S5 Table. Sensitivity analysis of disease occurrence probabilities. Values obtained from [6] (DOCX) S6 Table. Per-patient costs (USD), DALYs incurred, antibiotic overuse (Prob(over)) and underuse (Prob(under)) for febrile patients seeking care on the fourth day (average day) of illness and undergoing various test and treat strategies, with 75% antibiotic effectiveness. � = strategies on the effectiveness frontier (economically efficient) for Scenario A (bacterialendemic); º = strategies on the effectiveness frontier (economically efficient) for Scenario B (viral-endemic).…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the specific etiology, if untreated, patients could experience respiratory distress, multi-organ failure, and even death [2,3]. Due to climate change and the increasing counts of weather-related disasters [4][5][6], healthcare providers are facing a growing number of febrile illness patients, especially in low-resource settings [7]. The global annual burden of diseases under the umbrella of acute febrile illness is estimated to be on the order of millions of cases [8,9].…”

Section: Introductionmentioning

confidence: 99%

When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use

2020

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Background Febrile illness caused by viral and bacterial diseases (e.g., dengue and leptospirosis) often have similar symptoms and are difficult to differentiate without diagnostic tests. If not treated appropriately, patients may experience serious complications. The question of what diagnostic tests to make available to providers in order to inform antibiotic therapy remains an open problem for health services facing limited resources.

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“…Por se tratar de uma doença bacteriana que se apresenta clinicamente de diversos modos e com uma complexidade inerente à forma de transmissão, em que mais de duas centenas de possíveis reservatórios estão inter-relacionados com uma multidão de sorovares patogênicos, por si só já constitui um desafio para o adequado diagnóstico. Aliado a isso, a dificuldade em desenvolver tecnologias de diagnóstico de menor custo, precoce e acurado colabora para a incerteza quanto à real carga global da doença 14,15,20 .…”

Section: Conceito Ampliado De Negligência Para Com a Informação Em Saúdeunclassified

Sobre leptospirose e informação: ampliando os conceitos de negligência em saúde

Rodrigues

2017

ABCS Health Sci.

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Quando se utiliza a denominação “negligência” em saúde infere-se que não faltem recursos financeiros para lidar com determinadas doenças ou que existam tratamentos disponíveis, mas que são doenças ignoradas apesar de representarem um potencial risco ou um dano já instalado à saúde pública. O negligenciamento de uma doença possui um duplo significado. O primeiro faz menção ao discurso clássico da negligência decorrente da falta de ação dos atores centrais da saúde pública: indústria farmacêutica, governo e sistema de saúde. Já o segundo, em intrincado e concomitante arranjo, diz respeito ao negligenciamento das populações correlacionadas à pobreza, desenvolvendo um círculo vicioso que acorrenta, pelo menos, um bilhão de pessoas em todo o planeta, segundo dados da Organização Mundial de Saúde (OMS). Esta identifica apenas 17 doenças denominadas “negligenciadas” e que afetam populações de maior vulnerabilidade econômica e social, apesar de não incluir a leptospirose — uma zoonose emergente, endêmica e de incidência global. Tomando por proposta a ampliação do conceito de negligência em saúde, discute-se neste artigo o rompimento com o modelo hegemônico, levando-se em consideração o quanto desassistida seria a leptospirose como a antropozoonose de maior incidência mundial e com uma letalidade elevada em áreas de menor aporte econômico do planeta, apesar de não reconhecida em todo o seu potencial zoonótico por falta de dados confiáveis de carga de doença em populações humanas e animais.

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A Global, Multi-Disciplinary, Multi-Sectorial Initiative to Combat Leptospirosis: Global Leptospirosis Environmental Action Network (GLEAN)

Cited by 28 publications

References 13 publications

One Health contributions towards more effective and equitable approaches to health in low- and middle-income countries

One Health contributions towards more effective and equitable approaches to health in low- and middle-income countries

When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use

Sobre leptospirose e informação: ampliando os conceitos de negligência em saúde

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