The Setifian high-plains region, Northeast of Algeria, grapples with challenges in water resource management. As the water demand intensifies across a diverse range of sectors, assessing groundwater quality becomes indispensable. This article responds to the critical need for a thorough assessment of groundwater quality in the Wadi Boussellam sub-watershed. Employing a GIS-based method, we evaluate groundwater geochemistry by estimating the Water Quality Index (WQI), offering a comprehensive overview of water consumption. The analysis of groundwater samples reveals distinct facies, including calcic bicarbonate, calcic chloride, calcic sulfate, and magnesium sulfate, contributing to an enhanced understanding of the hydrochemical composition in the Setif region. Hydrochemical indices, specifically the WQI, Sodium Adsorption Ratio (SAR), and Na% are applied to assess groundwater suitability for various applications. The results indicate that most crops are generally suitable for irrigation, though they advise exercising caution with regard to human consumption. This study underscores the significance of regular monitoring to avert groundwater contamination and ensure sustainable use in the Setif region, providing insights that emphasize the ongoing necessity for efforts in water resource management and the preservation of this vital resource’s quality.