A glyphosate-based herbicide disrupted hematopoiesis and induced organ toxicities, ameliorated by vitamin B12 in a mouse model

Ngatuni, Douglas; Wairagu, Peninah M.; Jillani, Ngalla E.; Isaac, Alfred; Nyariki, James Nyabuga

doi:10.1016/j.sjbs.2022.03.028

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…However, only 38.13% exhibited the awareness regarding the potential environmental factors contributing to anemia. Environmental exposures to substances like benzene, herbicides, and pesticides have been documented to pose health risks, and their potential link to anemia has been explored in scientific literature (28)(29)(30). The underlying mechanisms include damaging the DNA in blood-forming cells, interfering with hormonal systems, disrupting endocrine function, or causing cellular damage (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

“…Environmental exposures to substances like benzene, herbicides, and pesticides have been documented to pose health risks, and their potential link to anemia has been explored in scientific literature (28)(29)(30). The underlying mechanisms include damaging the DNA in blood-forming cells, interfering with hormonal systems, disrupting endocrine function, or causing cellular damage (28)(29)(30). This finding has significant implications for public health education to address awareness gaps related to the etiological factors of anemia.…”

Section: Discussionmentioning

confidence: 99%

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Knowledge, attitudes, and practices among patients with anemia towards disease management

Yao,

Xu,

Cheng

et al. 2024

Front. Public Health

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ObjectiveThis study aimed to assess the knowledge, attitudes and practices among anemia patients toward disease management.MethodsThis web-based cross-sectional study was conducted between September and December 2023 at The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine). A self-designed questionnaire was developed to collect demographic information of anemia patients, and assess their knowledge, attitudes and practices (KAP) toward disease management.ResultsA total of 396 valid questionnaires were collected. The mean age of the participants was 57.44 ± 16.80 years, and 52.02% were female. The mean knowledge, attitudes, and practices scores were 11.47 ± 1.73 (possible range: 0–14), 27.32 ± 2.96 (possible range: 7–35), and 40.49 ± 6.06 (possible range: 10–50), respectively. Multivariate analysis showed that bachelor’s degree or above was independently associated with sufficient knowledge (OR = 2.372, 95%CI: 1.160–4.853, p = 0.018). Knowledge (OR = 1.350, 95%CI: 1.166–1.563, p < 0.001) and hemoglobin within 60-90 g/L (OR = 1.782, 95%CI: 1.090–2.912, p = 0.021) were independently associated with positive attitudes. Moreover, attitudes (OR = 1.618, 95%CI: 1.454–1.799, p < 0.001) and diagnosis ≥1 year (OR = 1.949, 95%CI: 1.171–3.243, p = 0.010) were independently associated with proactive practices. The path analysis demonstrated that knowledge was directly and positively correlated with attitudes (β = 0.484, 95% CI: 0.363–0.647, p = 0.008), and attitudes was directly and positively correlated with practices (β = 1.195, 95% CI: 1.062–1.332, p = 0.007). Moreover, knowledge was indirectly and positively correlated with practice (β = 0.579, 95% CI: 0.434–0.805, p = 0.004).ConclusionAnemia patients have sufficient knowledge, negative attitudes, but proactive practices toward the toward disease management Comprehensive training programs are needed to improve anemia patients practices in this area.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Knowledge, attitudes, and practices among patients with anemia towards disease management

Yao,

Xu,

Cheng

et al. 2024

Front. Public Health

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“…In agreement with the earlier fndings [58], SMB administration signifcantly depleted GSH levels in the liver, brain, and heart with elevation of GSH being observed in the spleen, lungs, and kidney, indicative of oxidative stress. Depletion of GSH is a clear indication of overwhelming and lethal oxidative stress levels, whereas it is characteristically associated with an initial response to rising levels of oxidative stress [59][60][61].…”

Section: Discussionmentioning

confidence: 99%

Sodium Metabisulfite-Induced Hematotoxicity, Oxidative Stress, and Organ Damage Ameliorated by Standardized Ginkgo biloba in Mice

Wairimu,

Wairagu,

Chepukosi

et al. 2023

Journal of Toxicology

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Sodium metabisulfite (SMB) is a biocide and antioxidant agent generally used as a preservative in food and beverage industries but can oxidize to harmful sulfite radicals. A standardized Ginkgo biloba (EGb-761) has demonstrated potent antioxidant and anti-inflammatory activities, which is beneficial for the treatment of diseases that exhibit oxidative stress and inflammation. The present study sought to investigate the putative ameliorative effects of EGb-761 against SMB-induced toxicity in mice. Thirty-two male Swiss white mice were randomized into control, SMB-treated, SMB + EGb-761-treated, and EGb-761-treated groups. EGb-761 (100 mg/kg/day) and SMB (98 mg/kg/day) were administered by gastric gavage for 40 days. Oral administration of EGb-761 restored SMB-induced decrease in body weight and prevented SMB-induced thrombocytopenia, leukocytosis, and anemia. Furthermore, EGb-761-treatment protected against SMB-induced liver and kidney injury depicted by decreased serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, bilirubin, creatinine, urea, uric acid, and albumin. Furthermore, EGb-761 treatment attenuated SMB-driven dyslipidemia and metabolic acidosis. Besides, EGb-761 supplementation abrogated SMB-driven oxidative stress as depicted by stabilized reduced glutathione (GSH) levels in the brain, liver, kidney, spleen, heart, and lungs. SMB induced a significant increase of tissue levels of malondialdehyde (MDA), serum nitric oxide (NO), interferon-gamma (IFN-γ) and tumor necrosis factor-α (TNF-α) which were abrogated by EGb-761 treatment. In conclusion, these results deepen our understanding of EGb-761 in light of various detrimental effects of SMB-driven toxicities. These findings provide a novel approach that can be optimized for preventing or treating exposure due to SMB toxicity.

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“…Another study reported that oral administration of 375 mg/kg of GBH for 56 days induced severe anemia, altered platelets and white blood cells, and caused in ammation and oxidative stress in mice. However, supplementation with vitamin B12 attenuated these effects, suggesting a potential role of antioxidants in managing GBH-induced toxicity (Ngatuni et al 2022). Additionally, a study demonstrated that intraperitoneal administration of glyphosate at levels of 25 and 50 mg/kg is clastogenic and cytotoxic to mouse bone marrow, potentially leading to decreased erythrocyte production in the mice (Prasad et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Association between Glyphosate Exposure and Erythrograms in a Representative Sample of US Adults: NHANES 2013–2014

Chang

Chu

Wang

et al. 2023

Environ Sci Pollut Res

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Glyphosate, being the most commonly utilized herbicide globally, and a growing body of experimental research has linked its exposure to red blood cell impairment. However, the potential toxicity of glyphosate exposure on erythrocytes in the general population remains poorly understood. Therefore, we analyzed data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) of 1466 adults (≥ 18 years) to explore the potential relationship between glyphosate exposure and erythrocyte pro les. Our results indicated a signi cant negative association between urinary glyphosate levels and hemoglobin (Hb) and hematocrit (Hct) in multiple regression analysis, with ß coe cients of -0.157 (S.E. = 0.055, P = 0.012) and − 0.431 (S.E. = 0.195, P = 0.043), respectively. Additionally, the odds ratio showed a signi cant increase in individuals with anemia with a one-unit increase in ln-glyphosate levels (odds ratio = 1.523 (95% CI = 1.301-1.783), P < 0.001 in the nal model). The negative correlation between glyphosate and Hb was more pronounced in subjects aged over 60 years, non-Hispanic white ethnicity, lower income, and those with a body mass index (BMI) < 25 and ≥ 30. In conclusion, our results offer initial evidence of a plausible link between glyphosate exposure and anemia among the adult populace in the United States. However, further research is necessary to comprehend the underlying mechanisms and clinical implications of this link.

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A glyphosate-based herbicide disrupted hematopoiesis and induced organ toxicities, ameliorated by vitamin B12 in a mouse model

Cited by 9 publications

References 37 publications

Knowledge, attitudes, and practices among patients with anemia towards disease management

Knowledge, attitudes, and practices among patients with anemia towards disease management

Sodium Metabisulfite-Induced Hematotoxicity, Oxidative Stress, and Organ Damage Ameliorated by Standardized Ginkgo biloba in Mice

Association between Glyphosate Exposure and Erythrograms in a Representative Sample of US Adults: NHANES 2013–2014

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