A Graphdiyne Oxide‐Based Iron Sponge with Photothermally Enhanced Tumor‐Specific Fenton Chemistry

Min, Huan; Qi, Yingqiu; Zhang, Yinlong; Han, Xuexiang; Cheng, Keman; Liu, Ying; Liu, Huibiao; Hu, Jianshe; Nie, Guangjun; Li, Yiye

doi:10.1002/adma.202000038

Cited by 106 publications

(95 citation statements)

References 37 publications

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“…Chen et al confirmed that the bacterial magnetic nanoparticles could induce increased level of intracellular ROS along with heat under near-infrared light irradiation to trigger an efficient tumor cell kill (Chen et al, 2016). Dong et al fabricated a nanoplatform based on iron oxide nanoparticles, indocyanine green, and hyaluronic acid (IONPs-ICG-HA) (Wang et al, 2019a more ROS by the heat produced in the process of photothermal therapy (Min et al, 2020). You et al designed a more stable and high-ROS-yielding Pt/Fe 3 O 4 @SP-PLGA lipo-polymersom, which could significantly increase the generation of •OH for ROS-mediated cancer therapy through the reaction between succinic peroxide (SP) and iron oxide under NIR irradiation (You et al, 2019 from H 2 O 2 on the VB of Fe 2 O 3 for antitumor therapy under irradiation of 650 nm laser (Figure 8) (Ou et al, 2020).…”

Section: External Field Enhanced Fenton Reactionmentioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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Ferrite nanoparticles have been widely used in the biomedical field (such as magnetic targeting, magnetic resonance imaging, magnetic hyperthermia, etc.) due to their appealing magnetic properties. In tumor acidic microenvironment, ferrite nanoparticles show intrinsic peroxidase-like activities, which can catalyze the Fenton reaction of hydrogen peroxide (H2O2) to produce highly toxic hydroxyl free radicals (•OH), causing the death of tumor cell. Recent progresses in this field have shown that the enzymatic activity of ferrite can be improved via converting external field energy such as alternating magnetic field and near-infrared laser into nanoscale heat to produce more •OH, enhancing the killing effect on tumor cells. On the other hand, combined with other nanomaterials or drugs for cascade reactions, the production of reactive oxygen species (ROS) can also be increased to obtain more efficient cancer therapy. In this review, we will discuss the current status and progress of the application of ferrite nanoparticles in ROS-mediated cancer therapy and try to provide new ideas for this area.

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Section: External Field Enhanced Fenton Reactionmentioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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“…As a result, GYD is softer than either graphyne or graphene. In the past three years, several studies have been conducted using GYD as a drug delivery platform for photothermal/chemotherapy combinatorial approach in cancer diagnosis [ 144 – 146 ].…”

Section: Nanomaterials Used For Cancer Treatmentmentioning

confidence: 99%

Nanomaterials for cancer therapy: current progress and perspectives

et al. 2021

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Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, and electrical properties. Nanomaterials used in cancer therapy can be classified into several main categories. Targeting cancer cells, tumor microenvironment, and immune system, these nanomaterials have been modified for a wide range of cancer therapies to overcome toxicity and lack of specificity, enhance drug capacity as well as bioavailability. Although the number of studies has been increasing, the number of approved nano-drugs has not increased much over the years. To better improve clinical translation, further research is needed for targeted drug delivery by nano-carriers to reduce toxicity, enhance permeability and retention effects, and minimize the shielding effect of protein corona. This review summarizes novel nanomaterials fabricated in research and clinical use, discusses current limitations and obstacles that hinder the translation from research to clinical use, and provides suggestions for more efficient adoption of nanomaterials in cancer therapy.

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“…Active targeting generally involves the employment of ligands to engage specific surface molecules which are expressed predominately by cancer cells. In this respect, an innovative iron sponge (TTIS) nanocomposite on basis of graphdiyne oxide was developed for acid responsive PTT/CDT (Min et al, 2020). To some extent, the high affinity for exceptional iron loading was exceedingly beneficial to provide abundant released iron under external stimulation for Fenton reaction.…”

Section: Design Of Nanomedicine For Ptt/cdtmentioning

confidence: 99%

“…(h) Biodistribution of Fe in major organs and tumors 6 and 12 hr after intravenous injection under magnetic targeting. (Reprinted with permission from Min et al (2020). Copyright 2020, WILEY‐VCH; Wu et al (2020).…”

Section: Design Of Nanomedicine For Ptt/cdtmentioning

confidence: 99%

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

Yao

Fang

Yao

et al. 2020

WIREs Nanomed Nanobiotechnol

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Given the diversity, complexity, and heterogeneity of persistent tumors, traditional nanoscale monotherapeutic systems suffer from dissatisfactory curative efficiency with incidence of metastasis or relapse. In parallel, the trend of clinical research on the basis of nanomedicines has increasingly shifted from monotherapy toward combinatorial therapy for admirable synergetic performances. In this regard, cutting‐edge nanomedicines harnessing photothermal‐chemodynamic bimodal therapy (PTT/CDT) have opened up a highly‐efficient and relatively‐safe cancer theranostic paradigm. Still, the integration of PTT/CDT functional units into one nanomedicine remains a herculean but meaningful task to achieve notable super‐additive effects. This review aims to elucidate underlying synergistic interactions of PTT/CDT and highlight intriguing designs of nanomedicines for PTT/CDT including nanomaterial selection, performance optimization, multimodal therapy, visualization strategies, and targeting strategies. Furthermore, an outlook on further improvements of PTT/CDT is provided, emphasizing significant scientific issues that require remediation for clinical translation. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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A Graphdiyne Oxide‐Based Iron Sponge with Photothermally Enhanced Tumor‐Specific Fenton Chemistry

Cited by 106 publications

References 37 publications

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Nanomaterials for cancer therapy: current progress and perspectives

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

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