A green and convenient approach for the synthesis of 1,10-phenanthrolines via a catalyst- and solvent-free condition

Abstract

An atom-efficient, catalyst-free, and one-pot multicomponent condensation of 8-hydroxyquinoline, aromatic aldehyde, acetoacetanilide, and ammonium acetate under solvent-free conditions is reported. This eco-friendly protocol offers several advantages such as a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, convergence, and facile automation.

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

“…Recently, several techniques for efficient application of solvent-free conditions or MCRs have been developed individually. However, when these two wings of green chemistry can be combined, an excellent green chemistry protocol is expected (13)(14)(15)(16).…”