A green fluorescence turn-off system for meclofenoxate determination by Cilefa Pink B dye

Hamad, Ahmed Abdulhafez

doi:10.1039/d2ra05128a

Cited by 15 publications

(5 citation statements)

References 44 publications

(50 reference statements)

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“…The greener analysis, the more valuable it is (given a high number). [ 42 ] This is because the procedure we created used methanol as a solvent, and no extraction, heating, or energy‐consuming processes were used per sample (less than 0.1 kW h). Using the eco‐scale, our designed approach scored 92, which indicated that our method was environmentally friendly [ 43 ] (Table 7).…”

Section: Resultsmentioning

confidence: 99%

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

et al. 2023

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Mitoxantrone (MXN) is a synthetic anthracenedione oncogenic therapy. It is often prescribed as an anticancer agent to manage a variety of cancers. A green, fast, and easy fluorimetric technique for the assay of MXN as a topoisomerase type II enzyme suppressor. An investigation of MXN's fluorescence behavior in various media and solvents constituted the basis for this new technique. Methanol was shown to enhance the intrinsic fluorescence considerably. After excitation at 610 nm, the highest fluorescence intensity was found at 675 nm. Various experimental parameters, such as media, solvents, and pH levels, were tested and adjusted. ICH (International Conference on Harmonization) guidelines were followed when validating procedures. It was possible to achieve linearity in the 0.02–1.50 μg ml−1 with the method. The sensitivity (in terms of limit of detection and limit of quantification) was 0.003 and 0.008 μg ml−1, indicating low toxicity. As a result, the current technology has a remarkable recovery for detecting residues in diverse bodily fluids. Also, the quantum yield was estimated for the designed system. Finally, the method was rated by eco‐scale scoring.

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Section: Resultsmentioning

confidence: 99%

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

et al. 2023

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“…It was discovered that distilled water exhibited the greatest efficacy and was the most suitable diluent for diluting the reaction medium. The observed phenomenon could potentially be attributed to a higher dielectric constant (80.2) and a greater polarity index of the water compared to the other solvents employed in the study [54–57].…”

Section: Resultsmentioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel‐blocking agents. This article presents a novel, simple, green, one‐pot‐processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular‐size‐dependent fluorescence augmentation of the light scattering‐driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL−1, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL−1, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio‐fluids (human plasma and urine). The developed method's eco‐friendliness was established by different eco‐rating metric tools.

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“…Biological and pharmaceutical analysts play a crucial role in protecting the environment and people from hazardous distribution media and organic residue [ 55 , 56 ]. The field of green analytical chemistry is in a state of continuous development and necessitates regular consideration.…”

Section: Resultsmentioning

confidence: 99%

The first facile optical density-dependent approach for the analysis of doxorubicin, an oncogenic agent accompanied with the co-prescribed drug; paclitaxel

Hamad

2023

BMC Chemistry

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Doxorubicin (DRB) is an anthracycline oncogenic drug extracted from cultures of Streptomyces peucetius var. caesius. It is frequently recommended as an anti-neoplastic agent for the treatment of diverse malignancies. It exerts its antineoplastic effect either via inhibiting the enzyme topoisomerase II and/or via intercalation to DNA or reactive oxygen species generation. In the present article, the direct, simple, one-pot, somewhat eco-safe, and non-extractive spectrophotometric system was executed to track doxorubicin, a chemotherapeutic remedy, in the presence of paclitaxel, a naturally occurring Taxan antineoplastic radical, through the greenness rated method. DRB’s optical density was studied in various mediums and solvents to develop the current approach. An acidic ethanolic solution was found to increase the optical density of the sample significantly. At 480 nm., the most remarkable optical density was obtained. Various experimental factors, including intrinsic media, solvent, pH, and stability time, were investigated and controlled. The current approach achieved linearity within the 0.6–40.0 µg mL-1 range, accompanied by a limit of both detection and quantification (LOD and LOQ) of 0.18 and 0.55 µg mL-1, correspondingly. The approach was validated under the ICH guidelines (Quality Guidelines). The system’s greenness and enhancement degree were estimated.

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A green fluorescence turn-off system for meclofenoxate determination by Cilefa Pink B dye

Abstract: The decoration of a facile switch-off fluorescent system utilizing a safe food dye (Cilefa Pink B) for meclofenoxate investigation through an electrostatic attachment.

Cited by 15 publications

References 44 publications

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

The first facile optical density-dependent approach for the analysis of doxorubicin, an oncogenic agent accompanied with the co-prescribed drug; paclitaxel

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