A Green Method Synthesis and Antimicrobial Activity of 2-Amino-4H-Chromene Derivatives

Abstract

Agro-waste stuff ash extracted solution have been emerging in recent practicing green reaction catalysis in organic synthesis. The derived media have been demonstrated in reactions like Sonogashira, Dakin, Henry, Suzuki-Miyaura, amide bond formation. Traditionally, these reactions were performed in organic solvents and used expensive catalysts with elevated temperature. These catalytic media showed distinct properties during reaction course such as, in situ base, homogeneous catalysts and reducing agent. The present work reviewed green protocol synthesis of 2-amino-4H-chromene derivatives employing reaction of substituted benzaldehyde, malononitrile and α/βnaphthol or resorcinol; three component reaction catalyzed in the presence of water extract of banana peel ash (WEB) extraction under microwave and grindstone methods is described. The reaction found eco-friendly, simple reaction condition with easy separation of final product in pure form. The final product was characterized for its homogeneity using spectroscopic techniques. Some of the selected chromene derivatives (3b, 3d, 3g) prepared in this method is tested for its in vitro antimicrobial studies. The bioassay revealed that products 3b and 3d showed positive response and comparable antimicrobial activity with the reference compounds.

An Efficient and Facile Synthesis of 2‐Amino‐4H‐pyrans &Tetrahydrobenzo[b]pyrans Catalysed by WEMFSA at Room Temperature

“…In view of present method findings, our group has also established other greener synthetic approaches to various other bioactive scaffold syntheses . From our observation, the developed agro‐waste media will be serving as a basic catalyst and it stands as a better alternative to the literature reported, which is not harmful to environment and proceeds in mild condition for the organic transformation processes.…”

“…[71,72] In view of present method findings, our group has also established other greener synthetic approaches to various other bioactive scaffold syntheses. [62,[88][89][90][91] From our observation, the developed agro-waste media will be serving as a basic catalyst and it stands as a better alternative to the literature reported, which is not harmful to environment and proceeds in mild condition for the organic transformation processes. [77] 15 6 e 60 87 202-203 201 [77] Synthesized products were characterized by FT-IR, 1 H-, 13 C-NMR, LC-MS and observed melting points are very much comparable with literature data.…”

Ultrasonic‐assisted preparation of Co3O4 and Eu‐doped Co3O4 nanocatalysts and their application for solvent‐free synthesis of 2‐amino‐4H‐benzochromenes under microwave irradiation

“…Water extract of banana peel ash (WEB) MW 2-8 7 2 -79 Kantharaju and Khatavi [59] Grindstone/H 2 O 1 5 -35…”

Aqueous Extract of Musa Acuminata: An Ecofriendly Catalyst for Knoevenagel Condensation

“…A large variety of catalysts have been reported by chemists in the recent decades like Al 2 O 3 , KF-Al 2 O 3 , K 10 -ZnCl 2 , Silica gel, USY-Zeolites, I 2 -K 2 CO 3 , Xonothite, Diammonium hydrogen phosphate, Basic-ionic liquid, ZnCl 2 , K 3 PO 4 , CTMAB, Zn(OAc) 2 , Poly urethane etc. [3][4][5][6][7][8][9][10][11] The Knoevenagel condensation is carried out in presence of bases as catalysts like amine, ammonia and their salts including TiCl 4 , LiCl, ZnO, MgO, ZrO 4 , Trizma, MgO nanoparticles, Fe(acac) 3 , Fe 2 O 3 @SiO 2 -PEG/en, MgO-NPs and Na 2 CaP 2 O 7 as catalysts. [12][13][14][15][16][17][18][19][20][21] However, these reported bases as catalysts led to various environmental issues, requires intense energy and specific conditions to occur.…”