A green protocol for the synthesis of quinoxaline derivatives catalyzed by polymer supported sulphanilic acid

Tarpada, Umesh P.; Thummar, Bhautik B.; Raval, Dipak K.

doi:10.1016/j.arabjc.2013.11.021

Cited by 25 publications

(5 citation statements)

References 31 publications

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“…1,2‐Diketo derivatives play an important role in organic synthesis, serving as synthetic intermediates of various heterocyclic compounds, [27a–c] natural products, [27d] and photosensitizers [28] . In particular, heterocycles containing 1,2‐diketo moiety are a paramount class of medicinally active scaffolds, for example, terpestacin [29] and dolutegravir, [30] clinically utilized as anti‐cancer and HIV‐1 integrase inhibitor respectively.…”

Section: Construction Of C−c Bondmentioning

confidence: 99%

Iron–Copper Dual Catalysis Enabling C−C and C−X (X=N, B, P, S, Sn) Bond Formation

Huo

Shi

2022

Eur J Org Chem

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Dedicated to Professor Zhen Yang on the occasion of his 63rd birthdayThe dual-catalysis tactics where two types of catalysts are connected in one single reaction operation are highly prized in the novel bond constructions that are difficult or unattainable to be achieved with current mono-catalysis. In recent years, increased emphasis on sustainable catalytic methods on more economic and eco-friendly processes has shifted the focus to catalysis with earth-abundant transition metals, such as iron, copper, and so on. As two of the most inexpensive and environmentally friendly metals on earth, the research and development based on either iron or copper catalysis are flourishing, and iron-copper dual-catalyzed reactions appeal more and more attention. In this review, we mainly cover the construction of CÀ C, CÀ N, CÀ B, CÀ P, CÀ S and CÀ Sn bonds enabled by iron-copper dual-catalysis published in the literature from 2011.

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Section: Construction Of C−c Bondmentioning

confidence: 99%

Iron–Copper Dual Catalysis Enabling C−C and C−X (X=N, B, P, S, Sn) Bond Formation

Huo

Shi

2022

Eur J Org Chem

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“…As expected, at reflux the reaction time is shorter than at room temperature. In addition, a slight increase in the amount of catalyst also shows resuts in a small increase in the yield of the desired products (Scheme 117, Path C) [241].…”

Section: Synthesis Of Quinoxalinesmentioning

confidence: 96%

Transition metal-free one-pot synthesis of nitrogen-containing heterocycles

et al. 2015

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One-pot heterocyclic synthesis is an exciting research area as it can open routes for the development of otherwise complex transformations in organic synthesis. Heterocyclic compounds show wide spectrum of applications in medicinal chemistry, chemical biology, and materials science. These heterocycles can be generated very efficiently through highly economical and viable routes using one-pot synthesis. In particular, the metal-free one-pot synthetic protocols are highly fascinating due to several advantages for the industrial production of heterocyclic frameworks. This comprehensive review is devoted to the transition metal-free one-pot synthesis of nitrogen-containing heterocycles from the period 2010-2013.

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“…The literature survey reveals that it has been applied as a catalyst for the synthesis of a variety of heterocyclic compounds. [32][33][34][35][36][37][38][39] The sulfanilic acid that occurs in solid form is present as a zwitterion. Sulfonic acid groups (-SO 3 H) can be deprotonated to become negative sulfonate (-SO 3 -) and amino groups which can be protonated to become positive ammonium groups (-NH 3 + ).…”

Section: Figure 1: Medicinal Properties Of β-Amino Ketonementioning

confidence: 99%

Sulfanilic acid catalysed one‐pot three‐component Mannich reaction for synthesis of β‐amino ketones

Kulkarni¹

2020

Vietnam Journal of Chemistry

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We have reported sulfanilic acid as an exceedingly competent catalyst for one‐pot Mannich reaction to give β‐amino carbonyl compounds in good to excellent yield within a short reaction time. The various organic acids have screened; like gallic acid, 4‐hydroxy benzoic acid, 4‐amino benzoic acid, phenylacetic acid, chloroacetic acid, sulfosalicylic acid, sulfanilic acid, chloro benzoic acid, phthalic acid, salicylic acid, cinnamic acid, hippuric acid, 1‐naphthyl acetic acid, o‐amino benzoic acid, p‐TSA, succinic acid, malic acid, and among them sulfanilic acid is a suitable catalyst. The reaction condition was optimized with respect to the solvent, the amount of catalyst as well as the variation of the ketone, aldehyde, and amine substrates. The procedure is mild, effective, ecofriendly, and the use of the minimum amount of catalyst.

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A green protocol for the synthesis of quinoxaline derivatives catalyzed by polymer supported sulphanilic acid

Cited by 25 publications

References 31 publications

Iron–Copper Dual Catalysis Enabling C−C and C−X (X=N, B, P, S, Sn) Bond Formation

Iron–Copper Dual Catalysis Enabling C−C and C−X (X=N, B, P, S, Sn) Bond Formation

Transition metal-free one-pot synthesis of nitrogen-containing heterocycles

Sulfanilic acid catalysed one‐pot three‐component Mannich reaction for synthesis of β‐amino ketones

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