A green tea extract and epigallocatechin-3-gallate attenuate the deleterious effects of irinotecan in an oral epithelial cell model

Vaillancourt, Katy; Lagha, Amel Ben; Grenier, Daniel

doi:10.1016/j.archoralbio.2021.105135

Cited by 14 publications

(9 citation statements)

References 32 publications

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“…In the terms of flavonoids and flavonoid glycosides, GTE mainly consisted of kaempferol-3-O-galactoside (Kae-3-O-Gal, 10.23 ± 0.97 mg/g) and myricetin-3-O-glucoside (Myr-3-O-Glu, 7.80 ± 0.70 mg/g) (Figure 1d). Previous studies have provided evidence that catechins, AA, and CAF decreased inflammatory response in oral epithelial cells, alleviated oral submucous fibrosis, and protected teeth against acid-induced erosion (De Moraes et al, 2021;Vaillancourt et al, 2021). Moreover, research has shown that oral administration of flavonoids like diosmin and hesperidin inhibited leukocytes adhering to the venular endothelium in the hamster cheek (Bouskela & Donyo, 1997).…”

Section: Assay Of Main Components In Gtementioning

confidence: 99%

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Pan,

Lv,

Zhang

et al. 2023

Journal of Food Science

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Oral cavity contains the second largest microbial community in the human body. Due to the highly vascularized feature of mouth, oral microbes could directly access the bloodstream and affect the host healthy systemically. The imbalance of oral microbiota is closely related to various oral and systemic diseases. Green tea extracts (GTE) mainly contain tea polyphenols, alkaloids, amino acid, flavones, and so on, which equipped with excellent anti‐inflammatory activities. Previous studies have demonstrated the beneficial effects of GTE on oral health. However, most researches used in vitro models or focused on limited microorganisms. In this study, the regulatory effect of GTE on oral microbiome and the alleviative effect on oral inflammation in vivo were evaluated. The results showed that GTE could efficiently alleviate the inflammations of the tongue, cheek pouch, as well as throat. GTE effectively inhibited the activation of NF‐κB through the upregulation of the anti‐inflammatory cytokine interleukin (IL)‐10, consequently leading to reduced expression of pro‐inflammatory cytokines IL‐6 and tumor necrosis factor‐α. The indexes of spleen and thymus were also elevated by GTE in stomatitis mice. Moreover, GTE promoted the growth of probiotics Lactobacillus and Bacillus, inhibited the reproduction of pathogens Achromobacter, reversing the microbiota disorders in oral cavity. This study not only presents a novel approach for enhancing oral microecology but also facilitates the wider adoption of tea consumption.

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Section: Assay Of Main Components In Gtementioning

confidence: 99%

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Pan,

Lv,

Zhang

et al. 2023

Journal of Food Science

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“…30,31 Moreover, previous research has revealed that EGCG shows anti-inflammatory properties by reducing the reactive oxygen species level of mucosal cells in an irinotecan-induced oral mucositis model; this is potentially one of the mechanisms by which EGCG alleviated the inflammation of the cheek pouch. 13…”

Section: Resultsmentioning

confidence: 99%

Epigallocatechin gallate (EGCG) alleviates the inflammatory response and recovers oral microbiota in acetic acid-induced oral inflammation mice

Pan,

Lv,

Feng

et al. 2023

Food Funct.

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“…In addition, GTE suppressed anorexia and weight loss caused by CPT-11. To date, it has been reported that GTE improves CPT-11-induced oral mucositis 37 . Therefore, taking GTE as a beverage or supplement during CPT-11 use may be a useful tool to reduce the adverse effects caused by CPT-11 and may contribute to improving the QOL of cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Green tea extract prevents CPT-11-induced diarrhea by regulating the gut microbiota

Kon

Ikarashi

Yamaguchi

et al. 2023

Sci Rep

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Irinotecan (CPT-11) is an anticancer drug with indications for use in treating various cancers, but severe diarrhea develops as a side effect. We investigated the effects of green tea extract (GTE) on CPT-11-induced diarrhea, focusing on β-glucuronidase and intestinal UGT1A1. When CPT-11 was administered to rats alone, the fecal water content was approximately 3.5-fold higher in this group than in the control group, and diarrhea developed. The fecal water content in the GTE-treated group was significantly higher than that in the control group, but the difference was smaller than that between the group treated with CPT-11 alone and the control group, and diarrhea improved. When CPT-11 was administered alone, the abundances of Bacteroidesfragilis and Escherichiacoli, which are β-glucuronidase-producing bacteria, increased and interleukin-6 and interleukin-1β mRNA levels in the colon increased, but GTE suppressed these increases. CPT-11 decreased colon UGT1A1 and short-chain fatty acid levels; however, this decrease was suppressed in the GTE-treated group. The findings that GTE decreases the abundance of β-glucuronidase-producing bacteria and increases colon UGT1A1 levels, thereby decreasing the production of the active metabolite SN-38 in the intestinal tract, indicate that GTE ameliorates CPT-11-induced diarrhea.

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A green tea extract and epigallocatechin-3-gallate attenuate the deleterious effects of irinotecan in an oral epithelial cell model

Cited by 14 publications

References 32 publications

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Epigallocatechin gallate (EGCG) alleviates the inflammatory response and recovers oral microbiota in acetic acid-induced oral inflammation mice

Green tea extract prevents CPT-11-induced diarrhea by regulating the gut microbiota

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