A greener approach for the synthesis of pyrido[2,3‐d]pyrimidine derivatives in glycerol under microwave heating

Abstract

Herein, we report the multicomponent synthesis of pyrido[2,3‐d]pyrimidine derivatives from 6‐aminouracil, aromatic aldehydes, and malononitrile in glycerol as a green solvent under microwave heating. This methodology shows several advantages: catalyst‐free synthesis, up to 90% yield, operational simplicity, short reaction times, easy work‐up procedure, and a greener approach compared with other methods reported in the literature.

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

“…In 2022, Martinho and his colleagues [111] released a report about their approach to creating pyrido[2,3‐ d ]‐pyrimidine 117 derivatives. They used glycerol as a green solvent and applied microwave heating to achieve good‐to‐excellent yields for various aldehydes 2 , including those with electron‐withdrawing and electron‐donating substituents on the aromatic ring.…”

Design, and Green synthetic approach of the Aryl-tetrazolo-[1,5-a][1,8]naphthyridine Molecules and their in vitro anti-microbial activity and In silico molecular modeling studies

“…Moreover, Microwave heating is expansively used as a convenient source of heating in organic synthesis reactions. The heating is instantaneous and extremely speci c. The pro t of microwave-supported organic synthesis is widely established and this technique is a simple, faster, and e cient technology, it is used to drop off the duration of time to carry diverse organic transformations along with high yield, lowest by-products, and minimum energy utilization with maximum selectivity [12][13][14][15][16]. In prolongation, of our foregoing studies on the development of eco-friendly green methodologies and construction of biological importance molecules [17][18][19][20][21] We report here in a facile and convenient synthetic strategy for the preparation of 4aryltetrazolo [1,5-a] [1,8]naphthyridine derivatives in the presence of simple glacial acetic acid formed high yield and these compounds showed interesting antimicrobial activity.…”