A guide and guard: The many faces of T-cadherin

Philippova, Maria; Joshi, Manjunath B.; Kyriakakis, Emmanouil; Pfaff, Dennis; Erné, Paul; Resink, Thérèse J.

doi:10.1016/j.cellsig.2009.01.035

Cited by 96 publications

(95 citation statements)

References 101 publications

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“…Minor variations in the molecular masses of T-cadherin in different tissues result largely from tissue-specific glycosylation (reviewed in ref. 29 and unpublished data). Importantly, T-cadherin was absent from any tissue examined from the knockout mice ( Fig.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 68%

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

Tyrberg

Miles

Azizian

et al. 2011

Islets

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Section: O N O T D I S T R I B U T Ementioning

confidence: 68%

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

Tyrberg

Miles

Azizian

et al. 2011

Islets

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“…96), reversal learning (repeated and motor modulation develop and are modified by pharmacological and physiological challenges (1,(32)(33)(34).…”

Section: Morris Water Mazementioning

confidence: 99%

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

Drgonová

Walther

Hartstein

et al. 2016

Mol Med

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The cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midbrain dopamine neurons. Human CDH13 mRNA expression differs by more than 80% in postmortem cerebral cortical samples from individuals with different CDH13 genotypes, supporting examination of mice with altered CDH13 expression as models for common human variation at this locus. Constitutive CDH13 knockout mice display evidence for changed cocaine reward: shifted dose response relationship in tests of cocaine-conditioned place preference using doses that do not alter cocaine-conditioned taste aversion. Reduced adult CDH13 expression in conditional knockouts also alters cocaine reward in ways that correlate with individual differences in cortical CDH13 mRNA levels. In control and comparison behavioral assessments, knockout mice display modestly quicker acquisition of rotarod and water maze tasks, with a trend toward faster acquisition of 5-choice serial reaction time tasks that otherwise displayed no genotype-related differences. They display significant differences in locomotion in some settings, with larger effects in males. In assessments of brain changes that might contribute to these behavioral differences, there are selective alterations of dopamine levels, dopamine/metabolite ratios, dopaminergic fiber densities and mRNA encoding the activity dependent transcription factor npas4 in cerebral cortex of knockout mice. These novel data and previously reported human associations of CDH13 variants with addiction, individual differences in responses to stimulant administration and attention deficit hyperactivity disorder (ADHD) phenotypes suggest that levels of CDH13 expression, through mechanisms likely to include effects on mesocortical dopamine, influence stimulant reward and may contribute modestly to cognitive and locomotor phenotypes relevant to ADHD.

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“…Thus, aggressive cancers are associated with decreased expression of E-cadherin which correlates with increased expression of desmosomal junction protein desmoglein (Kurzen et al, 2003) and N-cadherin (Gloushankova, 2008;Berx & van Roy, 2009). T-cadherin, a non-classical member of cadherin family, was also suggested to play a role in cancer progression Philippova et al, 2009 …”

Section: Introductionmentioning

confidence: 99%

Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature

Рубина¹,

Sysoeva²,

Semina³

et al. 2012

Tumor Angiogenesis

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A guide and guard: The many faces of T-cadherin

Cited by 96 publications

References 101 publications

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice

Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature

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