A guide to mechanobiology: Where biology and physics meet

Jansen, Karin A.; Donato, Dominique M.; Balcıoğlu, Hayri E.; Schmidt, Thomas; Danen, Erik H.J.; Koenderink, Gijsje H.

doi:10.1016/j.bbamcr.2015.05.007

Cited by 267 publications

(220 citation statements)

References 197 publications

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“…Some of these molecules are implicated in numerous pathways eventually dictating cell fate and functions. 4,5 Adhesion dynamics profoundly affects the RhoA/ROCK pathway, whose activity regulates the osteogenic/adipogenic fate of MSCs. 51 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 28 Cell-generated contractility might also impact at the transcriptional level directly.…”

Section: Effects Of Materials Features On Adhesion Proliferation and Mmentioning

confidence: 99%

Engineering Cell Instructive Materials To Control Cell Fate and Functions through Material Cues and Surface Patterning

Ventre

Netti

2016

ACS Appl. Mater. Interfaces

109

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Mastering the interaction between cells and extracellular environment is a fundamental prerequisite in order to engineer functional biomaterial interfaces able to instruct cells with specific commands. Such advanced biomaterials might find relevant application in prosthesis design, tissue engineering, diagnostics and stem cell biology. Because of the highly complex, dynamic, and multifaceted context, a thorough understanding of the cell-material crosstalk has not been achieved yet; however, a variety of material features including biological cues, topography, and mechanical properties have been proved to impact the strength and the nature of the cell-material interaction, eventually affecting cell fate and functions. Although the nature of these three signals may appear very different, they are equated by their participation in the same material-cytoskeleton crosstalk pathway as they regulate cell adhesion events. In this work we present recent and relevant findings on the material-induced cell responses, with a particular emphasis on how the presentation of biochemical/biophysical signals modulates cell behavior. Finally, we summarize and discuss the literature data to draw out unifying elements concerning cell recognition of and reaction to signals displayed by material surfaces.

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Section: Effects Of Materials Features On Adhesion Proliferation and Mmentioning

confidence: 99%

Engineering Cell Instructive Materials To Control Cell Fate and Functions through Material Cues and Surface Patterning

Ventre

Netti

2016

ACS Appl. Mater. Interfaces

109

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“…It is well recognized that beside biochemical input, the mechanical characteristics of a cell's environment can have a profound influence on its biological properties [3][4][5] . Neuronal and glial cells are sensitive to mechanical input during development, in disease and regenerative states [6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Acute but not inherited demyelination in mouse models leads to brain tissue stiffness changes

Eberle¹,

Fodelianaki²,

Kurth³

et al. 2018

Preprint

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The alteration or decrease of axonal myelination is an important hallmark of aging and disease. Demyelinated axons are impaired in their function and degenerate over time. Oligodendrocytes, the cells responsible for myelination of axons, are sensitive to mechanical properties of their environment. Growing evidence indicates that mechanical properties of demyelinating lesions are different from the healthy state and thus have the potential to affect myelinating potential of oligodendrocytes. We performed a high-resolution spatial mapping of the mechanical heterogeneity of demyelinating lesions using Atomic Force Microscope enabled indentation. Our results indicate that the stiffness of specific regions of mouse brain tissue is influenced by age and degree of myelination. Here we specifically demonstrate that acute but not inherited demyelination leads to decreased tissue stiffness, which could lower remyelination potential of oligodendrocytes. We also demonstrate that specific brain regions have unique ranges of stiffness in white and grey matter. Our ex vivo findings may help the design of future in vitro models to mimic mechanical environment of the brain in healthy and disease state. Reported here, mechanical properties of demyelinating lesions may facilitate novel approaches in treating demyelinating diseases such as multiple sclerosis.

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“…Exciting experiments in the field of mechanobiology have demonstrated that molecules, cells, and tissues are able to sense their environments and respond biologically to mechanical signals (1). Mechanical force is sensed by loadinduced changes in the conformation and/or activities of mechanosensitive macromolecules (i.e., mechanosensors), which in turn lead to a biological response.…”

mentioning

confidence: 99%

A Perspective on the Role of Myosins as Mechanosensors

Greenberg

Arpag

Tüzel

et al. 2016

Biophysical Journal

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Cells are dynamic systems that generate and respond to forces over a range of spatial and temporal scales, spanning from single molecules to tissues. Substantial progress has been made in recent years in identifying the molecules and pathways responsible for sensing and transducing mechanical signals to short-term cellular responses and longer-term changes in gene expression, cell identity, and tissue development. In this perspective article, we focus on myosin motors, as they not only function as the primary force generators in well-studied mechanobiological processes, but also act as key mechanosensors in diverse functions including intracellular transport, signaling, cell migration, muscle contraction, and sensory perception. We discuss how the biochemical and mechanical properties of different myosin isoforms are tuned to fulfill these roles in an array of cellular processes, and we highlight the underappreciated diversity of mechanosensing properties within the myosin superfamily. In particular, we use modeling and simulations to make predictions regarding how diversity in force sensing affects the lifetime of the actomyosin bond, the myosin power output, and the ability of myosin to respond to a perturbation in force for several nonprocessive myosin isoforms.

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A guide to mechanobiology: Where biology and physics meet

Cited by 267 publications

References 197 publications

Engineering Cell Instructive Materials To Control Cell Fate and Functions through Material Cues and Surface Patterning

Engineering Cell Instructive Materials To Control Cell Fate and Functions through Material Cues and Surface Patterning

Acute but not inherited demyelination in mouse models leads to brain tissue stiffness changes

A Perspective on the Role of Myosins as Mechanosensors

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