A head and neck hyperthermia applicator: Theoretical antenna array design

Paulides, Margarethus M.; Bakker, Jurriaan F.; Zwamborn, A.P.M.; Rhoon, Gerard C. van

doi:10.1080/02656730601150522

Cited by 52 publications

(41 citation statements)

References 22 publications

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“…3. Picture of the measurement setup with 12 antennas at staggered locations in two rings [20]. Also visible are 1) the centrally placed bottle containing saline water, 2) the gauze that forms the conducting backplane (limitedly visible) and separate conducting backplanes per antenna, and 3) the flat muscle phantom on which the antenna ring is positioned.…”

Section: Clinical Antenna Setup: Measurements and Simulationmentioning

confidence: 99%

“…In previous publications [2], [20] we have shown that the optimum setup for an H&N hyperthermia applicator is a circular array (diameter 40 cm) of two rings of six antennas (spacing between rings 6 cm). We constructed such a setup to measure the reflection characteristics of the patch antenna design within the applicator, and as such validate our theoretical analysis.…”

Section: Clinical Antenna Setup: Measurements and Simulationmentioning

confidence: 99%

“…Three arrangements of two antennas were investigated, i.e., horizontal (H-plane), diagonal and vertical (E-plane). The distance between the antennas was always 10 cm, since this is the worst case distance of the anticipated twelve antennas on a 40-cm diameter ring [20]. The combined influence of a patient was investigated by positioning a muscle layer at (muscle layer absent), 10 cm or 5 cm for all arrangements.…”

Section: Em Modelling 1) Ansoft Designermentioning

confidence: 99%

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A Patch Antenna Design for Application in a Phased-Array Head and Neck Hyperthermia Applicator

Paulides

Bakker

Chavannes

et al. 2007

IEEE Trans. Biomed. Eng.

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Abstract-In this paper, we describe a specifically designed patch antenna that can be used as the basis antenna element of a clinical phased-array head and neck hyperthermia applicator. Using electromagnetic simulations we optimized the dimensions of a probe-fed patch antenna design for operation at 433 MHz. By several optimization steps we could converge to a theoretical reflection of 38 dB and a bandwidth ( 15 dB) of 20 MHz (4.6%). Theoretically, the electrical performance of the antenna was satisfactory over a temperature range of 15 C-35 C, and stable for patient-antenna distances to as low as 4 cm. In an experimental cylindrical setup using six elements of the final patch design, we measured the impedance characteristics of the antenna 1) to establish its performance in the applicator and 2) to validate the simulations. For this experimental setup we simulated and measured comparable values: 21 dB reflection at 433 MHz and a bandwidth of 18.5 MHz. On the basis of this study, we anticipate good central interference of the fields of multiple antennas and conclude that this patch antenna design is very suitable for the clinical antenna array. In future research we will verify the electrical performance in a prototype applicator.

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Section: Clinical Antenna Setup: Measurements and Simulationmentioning

confidence: 99%

Section: Clinical Antenna Setup: Measurements and Simulationmentioning

confidence: 99%

Section: Em Modelling 1) Ansoft Designermentioning

confidence: 99%

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A Patch Antenna Design for Application in a Phased-Array Head and Neck Hyperthermia Applicator

Paulides

Bakker

Chavannes

et al. 2007

IEEE Trans. Biomed. Eng.

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“…The platform has also been used to develop a novel head and neck applicator [10,11] and to assess the safety of hyperthermia in the presence of metallic implants. It was validated on the basis of dosimetric measurements and clinical information.…”

Section: Rsfsroyalsocietypublishingorg Interface Focus 3: 20120058mentioning

confidence: 99%

A novel medical image data-based multi-physics simulation platform for computational life sciences

et al. 2013

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One contribution of 25 to a Theme Issue 'The virtual physiological human: integrative approaches to computational biomedicine'. Simulating and modelling complex biological systems in computational life sciences requires specialized software tools that can perform medical image data-based modelling, jointly visualize the data and computational results, and handle large, complex, realistic and often noisy anatomical models. The required novel solvers must provide the power to model the physics, biology and physiology of living tissue within the full complexity of the human anatomy (e.g. neuronal activity, perfusion and ultrasound propagation). A multi-physics simulation platform satisfying these requirements has been developed for applications including device development and optimization, safety assessment, basic research, and treatment planning. This simulation platform consists of detailed, parametrized anatomical models, a segmentation and meshing tool, a wide range of solvers and optimizers, a framework for the rapid development of specialized and parallelized finite element method solvers, a visualization toolkit-based visualization engine, a PYTHON scripting interface for customized applications, a coupling framework, and more. Core components are cross-platform compatible and use open formats. Several examples of applications are presented: hyperthermia cancer treatment planning, tumour growth modelling, evaluating the magneto-haemodynamic effect as a biomarker and physics-based morphing of anatomical models.

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“…Penetration deeper in tissue using a phased array of microwave antennas has been proposed (Arcangeli et al, 1984, Gross et al, 1990) and prototype arrays designed specifically for neck tumors are currently under development (Paulides et al, 2007b, Paulides et al, 2010, Togni et al, 2013. Radiofrequency phased-array systems are also available that can penetrate deep in the body, but the long wavelength generates a large heat focus (Canters et al, 2009, Van Rhoon et al, 2003, Fatehi and van Rhoon, 2008.…”

Section: Introductionmentioning

confidence: 99%

Tumor bed brachytherapy for locally advanced laryngeal cancer: a feasibility assessment of combination with ferromagnetic hyperthermia

Stauffer¹,

Vasilchenko²,

Osintsev³

et al. 2016

Biomed. Phys. Eng. Express

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Purpose. To assess the feasibility of adding hyperthermia to an original method of organ-preserving brachytherapy treatment for locally advanced head and neck tumors. Methods and materials. The method involves organ-preserving tumor resection and adjunctive high-dose-rate (HDR) brachytherapy delivered via afterloading catheters. These catheters are embedded in a polymeric implant prepared intraoperatively to fill the resection cavity, allowing precise computer planning of dose distribution in the surrounding at-risk tumor bed tissue. Theoretical and experimental analyzes address the feasibility of heating the tumor bed implant by coupling energy from a 100 kHz magnetic field applied externally into ferromagnetic particles, which are uniformly distributed within the implant. The goal is to combine adjuvant hyperthermia (40 °C-45 °C) to at-risk tissue within 5 mm of the resection cavity for thermal enhancement of radiation and chemotherapy response. Results. A fiveyear relapse free survival rate of 95.8% was obtained for a select group of 48 male patients with T3N0M0 larynx tumors, when combining organ-preserving surgery with HDR brachytherapy from a tumor bed implant. Anticipating the need for additional treatment in patients with more advanced disease, a theoretical analysis demonstrates the ability to heat at-risk tissue up to 10 mm from the surface of an implant filled with magnetically coupled ferromagnetic balls. Using a laboratory induction heating system, it takes just over 2 min to increase the target tissue temperature by 10 °C using a 19% volume fraction of ferromagnetic spheres in a 2 cm diameter silicone implant. Conclusion. The promising clinical results of a 48 patient pilot study demonstrate the feasibility of a new organ sparing treatment for laryngeal cancer. Anticipating the need for additional therapy, theoretical estimations of potential implant heating are confirmed with laboratory experiments, preparing the way for future implementation of a thermobrachytherapy implant approach for organ-sparing treatment of locally advanced laryngeal cancer.

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A head and neck hyperthermia applicator: Theoretical antenna array design

Cited by 52 publications

References 22 publications

A Patch Antenna Design for Application in a Phased-Array Head and Neck Hyperthermia Applicator

A Patch Antenna Design for Application in a Phased-Array Head and Neck Hyperthermia Applicator

A novel medical image data-based multi-physics simulation platform for computational life sciences

Tumor bed brachytherapy for locally advanced laryngeal cancer: a feasibility assessment of combination with ferromagnetic hyperthermia

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