A head to head comparison of oralvsintravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clots

Abstract

We demonstrate that the effect of oral omeprazole is as effective as intravenous therapy in terms of re-bleeding, surgery, transfusion requirements, hospitalization and mortality in patients with bleeding ulcers with low risk stigmata. These patients can be treated effectively with oral omeprazole.

High-dose vs. Low-dose Proton Pump Inhibitors post-endoscopic hemostasis in patients with bleeding peptic ulcer. A meta-analysis and meta-regression analysis

“…Ten of 859 screened RCTs were finally included (2,7,8,(11)(12)(13)(14)(15)(16)(17) with a total of 1.651 participants.…”

“…Seven studies had a score of 3 points (8,(12)(13)(14)(15)(16)(17), two studies of 2 points (2,7), and one study of 1 point (11), respectively.…”

“…All RCTs regarding low-versus high-dose PPI administration post-endoscopic hemostasis were identified (2,7,8,(11)(12)(13)(14)(15)(16)(17). In keeping with identification of suitable studies, the electronic databases Medline, Embase, PubMed, and the Cochrane Library were utilized to identify articles from 2000 to 2016 in the English language literature which included the following terms and/or amalgamations in their keyword lists, abstracts, or titles: RCT, double-blind, dexlansoprazole, omeprazole, lansoprazole, rabeprazole, esomeprazole, pantoprazole, high-dose PPI, low-dose PPI, PPI, and bleeding.…”

“…Consequently, hemorrhage after the primary endoscopic intervention could be considered as rebleeding. Actively bleeding patients were excluded in one study (16). Two studies (7,8) did not explicitly dismiss patients with bleeding ulcer and in whom it could not be ceased by endoscopy.…”

“…Hsu et al (13) reported mortality within 14 days. Three studies (7,8,16) reported a 30-day mortality, whereas Andriulli et al (14) reported only in-hospital mortality.…”