A Hemoglobin Based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) versus Hetastarch (HEX) in an Uncontrolled Liver Injury Hemorrhagic Shock Swine Model with Delayed Evacuation

A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation

“…Cardiac output was lower in HBOC-201-than HEX-treated pigs, but it was restored to baseline. As well, increased bleeding was not seen in a previously reported uncontrolled hemorrhage solid organ injury model [1]. Although, mildly increased pulmonary arterial pressure was present it is unclear to what extent it is clinically significant.…”

“…In contrast to other investigators, we did not observe differences between HBOC-201 and HEX groups regarding indirect indicators of tissue oxygenation (i.e., LA, BE, SO 2 ). However, in previous experiments with more severe HS, we observed a trend toward more rapid lactate clearance and significantly improved base excess in HBOC-201-in comparison to HEX-resuscitated pigs [1]. Manning et al reported a decrease in blood lactate levels with HBOC-201 in a similar swine uncontrolled HS liver injury model [5].…”

“…Investigation of hemoglobin-based oxygen carriers (HBOC) for use as primary resuscitation fluids for hemorrhagic shock (HS) causalities in the pre-hospital setting, where blood is not available (rural trauma or military operations), has recently gained prominence in trauma research [1][2][3][4]. HBOC are chemically modified hemoglobin solutions .…”

Sodium nitroprusside ameliorates systemic but not pulmonary HBOC-201-induced vasoconstriction: An exploratory study in a swine controlled haemorrhage model

“…Non-invasive Trans Cutaneous Oxygenation (TCOM) was continuously measured with a TCM4 Tina monitor (Radiometer, Copenhagen, Denmark). 4 Blood gas parameters, methaemoglobin and indirect oxygenation parameters were measured by blood gas analysis (ABL-750, Radiometer, Copenhagen, Denmark) at T0, T15, T30, T45, T60, T90, T105 and T120. Blood gas values were used to calculate derived parameters such as oxygen consumption (VO 2 ), delivery (DO 2 ) and extraction (see Supplementary material).…”

“…In experimental models of severe HS, resuscitation with some haemoglobin-based oxygen carriers (HBOC) decreases lactic acidosis and improves tissue oxygenation, haemodynamics, and survival. [1][2][3][4][5][6] This is of particular interest when blood is unavailable. 2 However, adverse events, including myocardial infarctions, related to systemic and pulmonary vasoconstriction were reported in HBOC clinical trials.…”