The 8-channel Multiple Use Silicon Photo-multiplier (SiPM) Integrated Circuit (MUSIC) Application specific integrated circuit (ASIC) for SiPM anode readout has been designed for applications where large photo-detection areas are required. MUSIC offers three main features: (1) Sum of the eight input channels using a differential output driver, (2) eight individual single ended (SE) analog outputs, and (3) eight individual SE binary outputs using a time over threshold technique. Each functionality, summation and individual readout includes a selectable dual-gain configuration. Moreover, the signal sum implements a dual-gain output providing a 15-bit dynamic range. The circuit contains a tunable pole zero cancellation of the SiPM recovery time constant to deal with most of the available SiPM devices in the market. Experimental tests show how MUSIC can linearly sum signals from different SiPMs and distinguish even a few photons. Additionally, it provides a single photon output pulse width at half maximum (FWHM) between 5–10 ns for the analog output and a single-photon time resolution (SPTR) around 118 ps sigma using a Hamamatsu SiPM S13360-3075CS for the binary output. Lastly, the summation mode has a power consumption of ≈200 mW, whereas the individual readout consumes ≈30 mW/ch.