A high-resolution anthropomorphic voxel-based tomographic phantom for proton therapy of the eye

Alghamdi, Ali A.; Ma, Anna; Marouli, M; Albarakati, Y.; Kacperek, Andrzej; Spyrou, N. M.

doi:10.1088/0031-9155/52/2/n02

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…Most eye dosimetry models were employed for radiation treatment planning and dose conversion factor calculation. 15 , 18 The voxel eye anthropomorphic phantom 19 employed in this study was based on 81 slices obtained from the female data of the Visible Human project. Semi-auto segmentation was carried out by color labeling each pixel.…”

Section: Methodsmentioning

confidence: 99%

MCNPX Estimation of Photoneutron Dose to Eye Voxel Anthropomorphic Phantom From 18 MV Linear Accelerator

Alghamdi

2023

Dose-Response

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The dose due to photoneutron contamination outside the field of irradiation can be significant when using high-energy linear accelerators. The eye is a radiation-sensitive organ, and this risk increases when high linear energy transfer neutron radiation is involved. This study aimed to provide a fast method to estimate photoneutron dose to the eye during radiotherapy. A typical high-energy linear accelerator operating at 18 MV was simulated using the Monte Carlo N-Particle Transport Code System extended version (MCNPX 2.5.0). The latest International Atomic Energy Agency photonuclear data library release was integrated into the code, accounting for the most known elements and isotopes used in typical linear accelerator construction. The photoneutron flux from a 5 × 5 cm2 field size was scored at the treatment table plane and used as a new source for estimating the absorbed dose in a high-resolution eye voxel anthropomorphic phantom. In addition, common shielding media were tested to reduce the photoneutron dose to the eye using common shielding materials. Introducing a 2 cm thickness of common neutron shielding medium reduced the total dose received in the eye voxel anthropomorphic phantom by 54%. In conclusion, individualized treatment based on photoneutron dose assessment is essential to better estimate the secondary dose inside or outside the field of irradiation.

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Section: Methodsmentioning

confidence: 99%

MCNPX Estimation of Photoneutron Dose to Eye Voxel Anthropomorphic Phantom From 18 MV Linear Accelerator

Alghamdi

2023

Dose-Response

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“…27,28 Other applications can be found in the planning of the proton therapy. 29 Physical phantoms for dosimetry are thus generally used for the validation of a virtual phantom for calculations, which find extensive application in telecommunication research (e.g. design of antennas for smartphones), and in medical industry (new products for diagnosis and treatments based on ionizing radiation).…”

Section: Reviewmentioning

confidence: 99%

“…Physical Film and blocks for OCT Phantoms for ultrasonography 19 development, 15 chambers and for retinal surgery tools for pharmacokinetic 39 development 36,38 Virtual Computational models with Anatomical eye phantoms for a spherical geometry for non-ionizing 21 and ionizing brachytherapy 27 dosimetry 28,29 OCT, optical coherence tomography.…”

Section: Non-anthropomorphic Anthropomorphicmentioning

confidence: 99%

Phantoms in medicine: The case of ophthalmology

et al. 2019

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Physical and in-silico phantoms have revealed extremely useful in the development of new surgical techniques and medical devices and for training purposes. The fabrication of eye phantoms requires knowledge of anatomy and physical principles beyond the eye physiology and medical instruments used in the clinical scenario. After a proper definition of phantoms and the discussion about their classification, the present work reviews the various phantoms developed in ophthalmology, illustrating the rationale of their design.

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“…In recent years, different eye models were presented based on the differences in sensitivity of eye zones (Alghamdi et al 2007;Behrens et al 2009;Nogueira et al 2011;Caracappa et al 2014). Till now, these models have been widely used for calculation of dose conversion coefficients of the eye lens (Behrens et al 2009;Behrens and Dietze 2010;Nogueira et al 2011;Manger et al 2012;Sakhaee et al 2015;Vejdani-Noghreiyan and EbrahimiKhankook 2016).…”

Section: Introductionmentioning

confidence: 99%

The effects of simulating a realistic eye model on the eye dose of an adult male undergoing head computed tomography

Akhlaghi

Ebrahimi-Khankook

Vejdani-Noghreiyan

2017

Radiat Environ Biophys

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In head computed tomography, radiation upon the eye lens (as an organ with high radiosensitivity) may cause lenticular opacity and cataracts. Therefore, quantitative dose assessment due to exposure of the eye lens and surrounding tissue is a matter of concern. For this purpose, an accurate eye model with realistic geometry and shape, in which different eye substructures are considered, is needed. To calculate the absorbed radiation dose of visual organs during head computed tomography scans, in this study, an existing sophisticated eye model was inserted at the related location in the head of the reference adult male phantom recommended by the International Commission on Radiological Protection (ICRP). Then absorbed doses and distributions of energy deposition in different parts of this eye model were calculated and compared with those based on a previous simple eye model. All calculations were done using the Monte Carlo code MCNP4C for tube voltages of 80, 100, 120 and 140 kVp. In spite of the similarity of total dose to the eye lens for both eye models, the dose delivered to the sensitive zone, which plays an important role in the induction of cataracts, was on average 3% higher for the sophisticated model as compared to the simple model. By increasing the tube voltage, differences between the total dose to the eye lens between the two phantoms decrease to 1%. Due to this level of agreement, use of the sophisticated eye model for patient dosimetry is not necessary. However, it still helps for an estimation of doses received by different eye substructures separately.

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A high-resolution anthropomorphic voxel-based tomographic phantom for proton therapy of the eye

Cited by 9 publications

References 15 publications

MCNPX Estimation of Photoneutron Dose to Eye Voxel Anthropomorphic Phantom From 18 MV Linear Accelerator

MCNPX Estimation of Photoneutron Dose to Eye Voxel Anthropomorphic Phantom From 18 MV Linear Accelerator

Phantoms in medicine: The case of ophthalmology

The effects of simulating a realistic eye model on the eye dose of an adult male undergoing head computed tomography

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