2011
DOI: 10.1016/j.chroma.2011.03.066
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A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography

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Cited by 39 publications
(9 citation statements)
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“…Hamman et al [124] developed a high-throughput screening approach for SFC, using six columns in the following sequence: Chiralpak ® AD-H, Lux ® Cellulose-1, Chiralcel ® OJ-H, Chiralpak ® IC, Chiralpak ® AS-H and Lux ® Cellulose-4. For screening, a 2.5 min gradient is used, starting with a linear increase from 10% to 55% modifier over 1.5 min and maintaining 55% modifier for one min.…”
Section: Screening Strategiesmentioning
confidence: 99%
“…Hamman et al [124] developed a high-throughput screening approach for SFC, using six columns in the following sequence: Chiralpak ® AD-H, Lux ® Cellulose-1, Chiralcel ® OJ-H, Chiralpak ® IC, Chiralpak ® AS-H and Lux ® Cellulose-4. For screening, a 2.5 min gradient is used, starting with a linear increase from 10% to 55% modifier over 1.5 min and maintaining 55% modifier for one min.…”
Section: Screening Strategiesmentioning
confidence: 99%
“…Since 2010, there were some studies concerning the use of chiral columns packed with smaller particles [[27], [28], [29], [30], [31], [32], [33]]. The mean diameter or particle size (d p ), of the spherical supports used for the stationary phase of a column is a physical dimension that has a significant impact on the performance of the column.…”
Section: Resultsmentioning
confidence: 99%
“…There were few investigations on the impact of 3 m CSP particles to speed up analysis maintaining resolution [17,18]. For the particular case of panthenol, in the selected operating conditions, some decrease in the flow rate was found to increase efficiency.…”
Section: Methods Developmentmentioning
confidence: 94%