A high-throughput screening method of bisphenols, bisphenols digycidyl ethers and their derivatives in dairy products by ultra-high performance liquid chromatography-tandem mass spectrometry

Cheng, Yan; Nie, Xin; Wu, Hanqiu; Hong, Yunhe; Yang, Bingcheng; Liu, Tong; Zhao, Dan; Wang, Jianfeng; Yao, Gui-Hong; Zhang, Feng

doi:10.1016/j.aca.2016.11.006

Cited by 50 publications

(24 citation statements)

References 29 publications

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“…The biggest difference can be observed for the MRM transition of BADGE·H 2 O·HCl, where the response obtained using MeOH is about 20 times higher than that obtained using ACN. This phenomenon has already been reported for this family of compounds [14, 16]. Moreover, the use of MeOH resulted in better peak shapes than those obtained using ACN.…”

Section: Resultssupporting

confidence: 75%

“…Hydrolyzed derivatives, such as BADGE·2H 2 O, BADGE·H 2 O, BFDGE·2H 2 O, and BFDGE·H 2 O, can be created during storage when food coatings come into contact with aqueous and acidic foodstuffs. Chlorinated derivatives, on the other hand, may be generated during the thermal coating treatment [14, 16]. In Table 1, key information about the BADGE and BFDGE derivatives is summarized.…”

Section: Introductionmentioning

confidence: 99%

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Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry

et al. 2019

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Bisphenol A diglycidyl ether (BADGE), bisphenol F diglycydyl ether (BFDGE), and their related compounds are widely used as precursors in production of epoxy resins. The high reactivity of these compounds makes the development of analytical methodologies that ensure appropriate metrological accuracy crucial. Consequently, we aimed to determine whether and to what extent the composition of the solution and storage conditions affect the stability of selected BADGE and BFDGE derivatives. The stabilities of these compounds were studied using liquid chromatography–tandem mass spectrometry with electrospray ionization (HPLC-ESI–MS/MS). The chromatographic method elaborated here has allowed for separation of the analytes in time shorter than 6 min, for both methanol and acetonitrile-based mobile phases. The obtained calibration curves for all analytes were linear in the range tested. The values of limit of detection (LODs) were in the range of 0.91–2.7 ng/mL, while values of limit of quantitation (LOQs) were in the range of 2.7–5.7 ng/mL. The chosen experimental conditions were compared in terms of the content of organic solvent in solution, storage temperature, and time. Our results show that the content of BADGE, BADGE·HCl, BFDGE, three-ring NOGE decreased with increasing water content (> 40% v / v ). For BADGE and three-ring NOGE, significant changes in concentration were noted as early as 24 h after the test solutions had been prepared. In addition, a reduction in the storage temperature (4 to − 20 °C) reduced the rate of transformation of the monitored analytes. Our study will increase quality control in future research and may increase the reliability of the obtained results. Graphical abstract Electronic supplementary material The online version of this article (10.1007/s00216-019-02016-5) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry

et al. 2019

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“…RSM has been used to evaluate the effects of multiple factors and levels on response variables [37][38][39][40]. The CCD of RSM was used to design and optimize some extraction and purification methods of macrolides.…”

Section: Optimization Of Clean-up By Response Surface Methodsmentioning

confidence: 99%

Targeted analysis of six emerging derivatives or metabolites together with 25 common macrolides in milk using Quick, Easy, Cheap, Effective, Rugged and Safe extraction and ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry

Wang

Ling

Zhou

et al. 2020

J of Separation Science

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An analytical method for the determination of six emerging derivatives or metabolites together with 25 common macrolides antibiotics in milk by ultraperformance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry was established. The samples were purified with optimized Quick, Easy, Cheap, Effective, Rugged, Safe methods. The amounts of primarysecondary amine, C18, and sodium acetate adsorbent materials were optimized by response surface method to obtain the best purification effect. The chromatographic separation was carried out using the XBridge-C18 (2.1 × 100 mm, 3.5 µm, Waters) column with mobile phase of acetonitrile with 0.1% v/v formic acid-water solutions (containing 10 mmol/L ammonium acetate), separated by gradient elution. The instrument was operated in the detection mode of electrospray positive and negative ions with Full MS/data dependent MS 2 acquisition mode detection, external standard method was used for quantitative analysis. The limits of detection and limits of quantitation of 31 compounds were 0.1-0.5 µg/L and 0.5-2.0 µg/L, respectively. A total of 31 compounds performed a good linearity in the range of 1 to 200 µg/L, and the correlation coefficient was greater than 0.990. The spiked recoveries in milk samples were 81.07-110.1% and the relative standard deviation was less than 5.1%. The method was successful applied to actual sample testing in the market.

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“…Although these methods play important roles in the detection of β-blockers, they also have some drawbacks. For example, the quantification of the ELISA method is not accurate and the operation is troublesome, and GC-MS involves derivative steps before chromatographic separation, which are time-consuming and which increase the possibility of contamination [18]. And the LC-UV method is limited by poor sensitivity, so it cannot meet the requirements for ultra-trace analyses.…”

Section: Introductionmentioning

confidence: 99%

Analysis of 27 β-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry

et al. 2019

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This paper presents an application of high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the analysis of 27 β-blockers and metabolites in milk powder. Homogenized milk power samples were extracted by acetonitrile and purified by using Oasis PRiME HLB solid-phase extraction cartridges. The Ascentis® C8 chromatographic column was used to separate the analytes. The quantification was achieved by using matrix-matched standard calibration curves with carazolol-d7 and propranolol-d7 as the internal standards. The results show an exceptional linear relationship with the concentrations of analytes over wide concentration ranges (0.5–500 μg kg−1) as all the fitting coefficients of determination r2 are > 0.995. All the limits of detection (LODs) and quantitation (LOQs) values were within the respective range of 0.2–1.5 μg kg−1 and 0.5–5.0 μg kg−1. Overall average recoveries were able to reach 66.1–100.4% with the intra- and inter-day variability under 10%. This method has been successfully applied to the screening of β-blockers and metabolites in commercial milk powders. At the same time, the corresponding characteristic fragmentation behavior of the 27 compounds was explored. The characteristic product ions were determined and applied to the actual samples screening.

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A high-throughput screening method of bisphenols, bisphenols digycidyl ethers and their derivatives in dairy products by ultra-high performance liquid chromatography-tandem mass spectrometry

Cited by 50 publications

References 29 publications

Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry

Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry

Targeted analysis of six emerging derivatives or metabolites together with 25 common macrolides in milk using Quick, Easy, Cheap, Effective, Rugged and Safe extraction and ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry

Analysis of 27 β-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry

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