A High-Yield Process for Extraction of Hesperidin from Orange (Citrus sinensis L. osbeck) Peels Waste, and Its Transformation to Diosmetin, A Valuable and Bioactive Flavonoid

Victor, Maurício M.; David, Jorge M.; Cortez, Maria V. M.; Leite, Juliana Lago; Silva, Gálber S. B. da

doi:10.1007/s12649-020-00982-x

Cited by 49 publications

(35 citation statements)

References 28 publications

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“…Victor et al [ 25 ] and Lagha-Benamrouche et al [ 26 ] reached similar results than the reported in this study but using higher times of extraction. Other authors optimized the phenolic extraction from the orange peel by other methods as high voltage electrical discharges [ 6 ], microwave-assisted extraction [ 27 ], and pressurized liquid extraction [ 3 ], but they noticed lower yields compared to our results ( Table 4 ).…”

Section: Resultssupporting

confidence: 89%

Optimization of Ultrasound-Assisted Extraction via Sonotrode of Phenolic Compounds from Orange By-Products

Razola-Díaz

Guerra‐Hernández

Rodríguez‐Pérez

et al. 2021

Foods

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Orange peel is the main by-product from orange juice industry. It is a known source of bioactive compounds, mostly phenolic compounds, and it has been widely studied for its healthy activities. Thus, this research focuses on the establishment of ultrasound-assisted extraction of phenolic compounds in orange peel using a sonotrode. For this purpose, a Box–Behnken design of 27 experiments was carried out with four independent factors—ratio ethanol/water (v/v), time (min), amplitude (%), and pulse (%). Quantitative analyses of phenolic compounds were performed and the antioxidant activity was measured by ABTS and DPPH methods. The validity of the experimental design was confirmed by ANOVA and the optimal sonotrode extraction conditions were obtained by response surface methodology (RSM). The extracts obtained in the established conditions were analyzed by High Performance Liquid Chromatography (HPLC) coupled to mass spectrometer detector and 74 polar compounds were identified. The highest phenolic content and antioxidant activity were obtained using 45/55 ethanol/water (v/v), 35 min, amplitude 90% (110 W), and pulse 100%. The established method allows an increment of phenolics recovery up to 60% higher than a conventional extraction. Moreover, the effect of drying on phenolic content was also evaluated.

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Section: Resultssupporting

confidence: 89%

Optimization of Ultrasound-Assisted Extraction via Sonotrode of Phenolic Compounds from Orange By-Products

Razola-Díaz

Guerra‐Hernández

Rodríguez‐Pérez

et al. 2021

Foods

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“…Compounds such as baicalin, baicalein, naringenin, naringin, eugenol and methyl eugenol can be found in several other higher plants 86 , 91 . In addition, these compounds were also reported to be present in agro-industrial waste of Citrus 92 , 93 and apple pomace 94 , 95 .…”

Section: Challenges and Opportunitiesmentioning

confidence: 96%

Efficacy and sustainability of natural products in COVID-19 treatment development: opportunities and challenges in using agro-industrial waste from Citrus and apple

Antonio

Wiedemann

Galante

et al. 2021

Heliyon

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Natural products have been used in the treatment of illnesses throughout the history of humankind. Exploitation of bioactive compounds from natural sources can aid in the discovery of new drugs, provide the scaffold of new medicines. In the face of challenging diseases, such as the COVID-19 pandemic, for which there was no effective treatment, nature could offer insights as to novel therapeutic options for control measures. However, the environmental impact and supply chain of bioactive production must be carefully evaluated to ensure the detrimental effects will not outweigh the potential benefits gained. History has already proven that highly bioactive compounds can be rare and not suitable for medicinal exploitation; therefore, the sustainability must be accessed before expensive, time-demanding, and large trials can be initialized. A sustainable option to readily produce a phytotherapy with minimal environmental stress is the use of agro-industry wastes, a by-product produced in high quantities. In this review we evaluate the sustainability issues associated with the production of phytotherapy as a readily available tool for pandemic control.

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“…Hernández-Carranza et al (2015) needed 60 °C during 12 h using water as solvent for obtaining 6.89 mg GAE/g d.w. [13]. Using methanol as solvent Victor et al, (2020) obtained 28 mg GAE/g d.w. needing 3 h at 55 °C [14], and Lagha-Benamrouche et al, (2013) obtained 25.60 mg GAE/g d.w. needing 22 h at 20 °C [15]. Also, other author has used ultrasound technology to optimize the extraction of phenolic compounds from the orange peel.…”

Section: Confirmation Of Optimal Sonotrode Ultrasound Parametersmentioning

confidence: 97%

Optimization of Ultrasound Assisted Extraction of Phenolic Compounds from Orange By-Product

Razola-Díaz

Guerra‐Hernández

Rodríguez‐Pérez

et al. 2020

The 1st International Electronic Conference on Food Science and Functional Foods

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Orange peel (OP) is the main by-product from orange juice industry. OP is a known source of bioactive compounds and is widely studied for its antioxidant, anti-inflammatory, anti-cancer, anti-rheumatic, anti-diabetic and cardioprotective activities. Thus, this research focuses on the establishments of ultrasound-assisted extraction of phenolic compounds in orange peel using a sonotrode; objective framed in the European SHEALTHY (non-thermal physical technologies to preserve healthiness of fresh and minimally processed fruit and vegetables) project. For this purpose, a Box Behnken design of 27 experiments was carried out with 4 independent factors (ratio ethanol/water, time (min), amplitude (%) and pulse (%)). Quantitative analyses of total phenolic compounds (TPC) were performed by Folin-Ciocalteu method and the antioxidant activity was measured by ABTS and DPPH methods. The validity of the experimental design was confirmed by ANOVA and the optimal sonotrode extraction conditions were obtained by response surface methodology. The optimal extracts were characterized by HPLC coupled to mass spectrometer detectors. The highest phenolic content and antioxidant activity was obtained using 45/55 ethanol/water (v/v), 35 min, amplitude 90% (110 W) and pulse 100%. The established method allows the extraction of 30.42 mg of gallic acid equivalents/g dry weight of total phenolic compounds from OP; this value suppose an increment up to 60% higher than conventional extraction.

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A High-Yield Process for Extraction of Hesperidin from Orange (Citrus sinensis L. osbeck) Peels Waste, and Its Transformation to Diosmetin, A Valuable and Bioactive Flavonoid

Cited by 49 publications

References 28 publications

Optimization of Ultrasound-Assisted Extraction via Sonotrode of Phenolic Compounds from Orange By-Products

Optimization of Ultrasound-Assisted Extraction via Sonotrode of Phenolic Compounds from Orange By-Products

Efficacy and sustainability of natural products in COVID-19 treatment development: opportunities and challenges in using agro-industrial waste from Citrus and apple

Optimization of Ultrasound Assisted Extraction of Phenolic Compounds from Orange By-Product

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