2022
DOI: 10.1002/anie.202215013
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A Highly Compatible Phototrophic Community for Carbon‐Negative Biosynthesis

Abstract: CO2 sequestration engineering is promising for carbon‐negative biosynthesis, and artificial communities can solve more complex problems than monocultures. However, obtaining an ideal photosynthetic community is still a great challenge. Herein, we describe the development of a highly compatible photosynthetic community (HCPC) by integrating a sucrose‐producing CO2 sequestration module and a super‐coupled module. The cyanobacteria CO2 sequestration module was obtained using stepwise metabolic engineering and the… Show more

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Cited by 22 publications
(15 citation statements)
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“…Additional expression of a sucrose porin (cscY) and a sucrose operon repressor (cscR) further improved sucrose utilization (Löwe et al, 2020), while further optimization of the nitrogen-deficiency response pathway (Hobmeier et al, 2020) and culture conditions could boost PHA titer further (Kratzl et al, 2023; Table 2). Other co-culture products include the metabolites ethylene, isoprene, 3-hydroxypropionic acid (3-HP), and 2,3-butanediol (Table 2), which are compounds in a broader class of industrially relevant precursors widely used for chemical synthesis (e.g., diols, organic acids, gaseous alkenes; Cui et al, 2022;Li C. et al, 2022;Ma et al, 2022). In most of these reports, the heterotrophic microbe utilized were E. coli substrains, although the rapidly growing halophile Vibrio natriegens was able to produce a relatively high amount of 2,3-butanediol in co-culture (Li C. et al, 2022).…”
Section: Cyanobacterial Co-culture As a Flexible Platform For Value-a...mentioning
confidence: 99%
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“…Additional expression of a sucrose porin (cscY) and a sucrose operon repressor (cscR) further improved sucrose utilization (Löwe et al, 2020), while further optimization of the nitrogen-deficiency response pathway (Hobmeier et al, 2020) and culture conditions could boost PHA titer further (Kratzl et al, 2023; Table 2). Other co-culture products include the metabolites ethylene, isoprene, 3-hydroxypropionic acid (3-HP), and 2,3-butanediol (Table 2), which are compounds in a broader class of industrially relevant precursors widely used for chemical synthesis (e.g., diols, organic acids, gaseous alkenes; Cui et al, 2022;Li C. et al, 2022;Ma et al, 2022). In most of these reports, the heterotrophic microbe utilized were E. coli substrains, although the rapidly growing halophile Vibrio natriegens was able to produce a relatively high amount of 2,3-butanediol in co-culture (Li C. et al, 2022).…”
Section: Cyanobacterial Co-culture As a Flexible Platform For Value-a...mentioning
confidence: 99%
“…The cosmetic p-coumaric acid, is another highervalue compound useful for its antioxidant and antimicrobial properties (Boz, 2015;Boo, 2019). The biosynthetic pathway for p-coumaric acid was introduced into V. natriegens and co-cultures of these engineered strains with S. elongatus PCC 7942 allowed for photosynthetically driven p-coumaric acid production (Li C. et al, 2022). Other recent reports provide further evidence of the flexibility of this cyanobacterial co-cultivation system (see Table 2), including bioproduction of fatty acids (Li C. et al, 2022), ε-caprolactone (Toth et al, 2022), lactate (Li C. et al, 2022), and secreted enzymes (Hays et al, 2017).…”
Section: Cyanobacterial Co-culture As a Flexible Platform For Value-a...mentioning
confidence: 99%
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