A highly efficient, in situ wet-adhesive dextran derivative sponge for rapid hemostasis

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

“…When the dextran is oxidized less than 60%, it can slowly bind into the tissues, because the tissue-material adhesion force, local inflammation and systemic tissue toxicity is extensively relied on the number and density of aldehyde groups (Bhatia et al, 2007a). Liu et al (2019) designed a kind of aldehyde dextran (PDA) sponge with good water absorption and adhesive behaviors (Figure 8). After optimization of pore size, PDA sponge displayed the quick blood absorption, powerful tissue adhesion and effective hemostasis on the rabbit models, because the quick coagulation process of PDA sponge could accelerate the wound block, cell aggregation and cell initiation without the need for coagulation cascade activation (Liu et al, 2019).…”

“…Liu et al (2019) designed a kind of aldehyde dextran (PDA) sponge with good water absorption and adhesive behaviors (Figure 8). After optimization of pore size, PDA sponge displayed the quick blood absorption, powerful tissue adhesion and effective hemostasis on the rabbit models, because the quick coagulation process of PDA sponge could accelerate the wound block, cell aggregation and cell initiation without the need for coagulation cascade activation (Liu et al, 2019). Artzi et al (2009Artzi et al ( , 2011 prepared a kind of sealant consisting of star-shaped PEG-NH 2 and Dex-CHO with various molecular weights and aldehyde oxidation degrees, exhibiting effective tissue adhesion behaviors after chemical modification.…”

“… Liu et al (2019) designed a kind of aldehyde dextran (PDA) sponge with good water absorption and adhesive behaviors ( Figure 8 ). After optimization of pore size, PDA sponge displayed the quick blood absorption, powerful tissue adhesion and effective hemostasis on the rabbit models, because the quick coagulation process of PDA sponge could accelerate the wound block, cell aggregation and cell initiation without the need for coagulation cascade activation ( Liu et al, 2019 ).…”

Continuous production of uniform chitosan beads as hemostatic dressings by a facile flow injection method

“…The absorbance at 540 nm was recorded using a microplate reader. 28 Statistical analysis. The data were reported as means AE standard deviation (SD).…”

Highly Tough, Stretchable, Self‐Adhesive and Strain‐Sensitive DNA‐Inspired Hydrogels for Monitoring Human Motion

“…Different from conventional medical sutures, which easily causes econdaryt raumaa nd pain, tissue adhesive can not only reduce patients's uffering,b ut also maintain the abilities of woundc losing, hemostasis,a nd even promoting woundr ecovery. [19][20][21] According to the interaction mechanism, current tissuea dhesives can be classified as interfacial covalenta dhesives, [22][23][24] supramolecular adhesives, [25][26][27] hydrogen-bond adhesives, [28][29][30] ands of orth. These adhesives all exhibit preferable performance on tissue adhesion.A mong them, the noncovalenta dhesives, especially the hydrogen-bond adhesives, have been paid more and more attention due to their low cost, easy operability and lack of residues.…”