A highly parallel picoliter dispenser with an integrated, novel capillary channel structure

Steinert, Chris P.; Goutier, Ingo; Gutmann, Oliver; Sandmaier, H.; Daub, Martina; Heij, Bas de; Zengerle, Roland

doi:10.1016/j.sna.2004.04.007

Cited by 39 publications

(14 citation statements)

References 8 publications

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“…These techniques employ inkjet technology or other advanced microfluidic devices. [47,132] The second category requires a gentle contact between a pin, or a capillary, with a surface to transfer a small volume of protein solution onto the surface. [47,48] Both contact and non-contact techniques are attractive for their versatility, high throughput, and ability to pattern large numbers of different types of protein.…”

Section: Microfluidics For Surface Processingmentioning

confidence: 99%

Microfluidics for Processing Surfaces and Miniaturizing Biological Assays

2005

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This review is an account of our efforts to develop a versatile and flexible microfluidic technology for surface‐processing applications and miniaturizing biological assays. The review is presented in the context of current trends in microfluidic technology and addresses some of the major challenges for confining chemical and biochemical processes on surfaces: the sealing of a microchannel with a surface, the world‐to‐chip interface, the displacement of liquids in small conduits, the sequential delivery of multiple solutions, the accurate patterning of surfaces, the coincident detection of various analytes, and the detection of analytes in a small and dilute sample. Our solutions to these problems include the use of reversible sealing, capillary phenomena for powering and controlling liquid transport, and non‐contact microfluidics for spotting and drawing (on surfaces) with flow conditions. These solutions offer many advantages over conventional techniques for handling minute amounts of liquids and may find applications in lithography, biopatterning (e.g., the patterning of biomolecules), diagnostics, drug discovery, and also cellular assays.

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Section: Microfluidics For Surface Processingmentioning

confidence: 99%

Microfluidics for Processing Surfaces and Miniaturizing Biological Assays

2005

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“…Over the century, fluid ejectors or dispensers were used in wide applications of biotechnology, [1][2][3] integrated circuit manufacturing, 4,5 and engineering. 6,7 In general, those devices are mainly classified into two types: the continuous jet and the drop-on-demand jet.…”

Section: Introductionmentioning

confidence: 99%

Piezoelectric dispenser based on a piezoelectric-metal-cavity actuator

Lam

Sun

Kwok

et al. 2009

Review of Scientific Instruments

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A piezoelectric dispenser has been fabricated based on the idea of a piezoelectric-metal-cavity ͑PMC͒ actuator. The PMC actuator consists of a metal ring sandwiched between two identical piezoelectric unimorphs. The radial contraction of the piezoelectric ceramic is converted into a flextensional motion of the unimorph, causing a large flexural displacement in the center part of the actuator. With the PMC actuator as a fluid chamber, the large flexural actuation can be used to produce the displacement needed to eject fluid. By applying an appropriate voltage to the piezoelectric unimorphs, a drop-on-demand ejection of ink or water can be achieved. The efficiency of fluid ejection can be enhanced after installing a valve in the fluid chamber. With the simple PMC structure, the dispenser can be operated with a low driving voltage of 12-15 V.

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“…[8][9][10] Most recently, some ink-jet devices are being applied to biological chemistry, and are used for the preparation and placement of a nano-or micro-liter amount of liquid sample for DNA micro arrays. [11][12][13][14][15] Nilsson et al applied a flow-through type micro-dispenser with piezoelectric elements to the interface a liquid chromatograph and a gel electrophoretic apparatus. 16 The ink-jet microdispenser was also used as a spotting device for protein analysis in matrix-assisted laser desorption/ionization (MALDI) time-offlight mass spectrometry (TOF-MS).…”

Section: Introductionmentioning

confidence: 99%