A highly selective aggregation‐induced emission fluorogen for sensitive detection of Al³⁺ in living cells

Abstract

A Schiff's base derivative was synthesized using a condensation reaction between 8formyl-7-hydroxy-4-methylcoumarin and furan-2-carbohydrazide that produced marked aggregation-induced emission and had excellent ability to specifically recognize aluminium ions (Al 3+ ). This compound displayed faint fluorescence in the benign solvent dimethyl formamide, and exhibited obvious green fluorescence following addition of specific amounts of water. Moreover, it exhibited strong blue fluorescence after combination with Al 3+ even in the presence of other interfering ions.These experimental results demonstrated that this derivative could be used as a fluorescence probe for Al 3+ . The advantages, including significant fluorescence change, high selectivity and sensitivity, and fast response, meant that this probe could be used both to detect Al 3+ in water samples and for fluorescence imaging in living cells.

Water-soluble optical sensors: keys to detect aluminium in biological environment

“…Recently, in 2019, Li and coworkers have reported a Schiff's base derivative (23), which shows a marked AIE response and specic Al 3+ ion binding property. 74 The weakly-uorescent Schiff's base compound in DMF turns into a strong green-emissive solution with an emission maximum of about 510 nm upon the addition of more than 40% water (schematically, the AIE process and Al 3+ sensing are demonstrated in Fig. 18a and b).…”

A ratiometric fluorescent probe for the rapid and specific detection of HSO3− in water samples

“…− detection methods such as electrochemistry, [16] chromatography, [17] and spectroscopy, [18] fluorescence analysis has received much attention due to its high specificity and sensitivity, real-time monitoring, and in situ analysis. [19][20][21][22][23][24][25] To date, many various types of fluorescent probes have been developed for HSO 3 − . However, many of these are single-signal fluorescent probes [26][27][28][29][30][31][32][33][34][35] that are often influenced by many factors such as external detection environment conditions, photo-bleaching effects, stability of instruments, background signals, and probe distribution.…”