A highly selective chromogenic and fluorogenic chemodosimeter for dual detection of Cu²⁺ based on a redox-active calix[4]arene with isoxazolylchloroanthracene

Abstract

Calix[4]arene 1 with 25,27-diisoxazolylchloroanthryl groups is a chromogenic and fluorogenic sensor for Cu2+ with a LOD of 1.67 μM by fluorescence. Calix[4]diquinone was obtained in high yield through the redox reaction of ligand 1 with Cu(ClO4)2.

Highly selective Cu2+ detection with a naphthalimide-functionalised pillar[5]arene fluorescent chemosensor

“…14–16 More recently, we reported the development of a highly selective chromogenic and fluorogenic chemodosimeter for Cu 2+ ions, comprising calix[4]arene with lower-rim distal isoxazolylchloroanthryl groups. 17…”

Camptothecin-loaded supramolecular nanodelivery system based on amphiphilic calix[4]arene for targeted tumor therapy

“…32,33 On the other hand, taking advantage of the rapid development of nanotechnology, calixarene-based supramolecular nano drug delivery provides an alternative pathway to improve tumor accumulation relying on passive targeting to realize an enhanced permeability and retention (EPR) effect. 34,35 Despite these significant achievements, the drawbacks of high tumor accumulation have not yet been adequately addressed. Poor drug release at the target site due to the slow degradation rate of the nanocarrier can lead to off-target reactivity or premature drug leakage in the systemic circulation.…”

Development of multi-analyte responsive sensors: optical discrimination of arsenite and arsenate ions, ratiometric detection of arsenite, and application in food and water samples

“…Many attempts have been made in recent years to sense various anions and cations using chromogenic and fluorogenic methods. 18–23 Most of these chemosensors were designed for monitoring the environment-polluting ions with precise detection and quantification. 20,24–30…”