A highly selective turn-on schiff base fluorescent sensor for diabetic biomarker beta-hydroxybutyrate (β-HB)

Wang, Jin; Li, Na; Yang, Xiaoqin; Wang, Lili; Ni, Rui-Yao; He, Ying-Ning; Zhang, Ce

doi:10.1016/j.dyepig.2022.110765

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…70 An implanted fluorescent sensor has been proposed but no clinical data on this method have been reported. 71 Theoretically, a combined continuous glucose monitor (CGM) and CKM system, offering both continuous glucose and ketone data within a single system, may be feasible. 72 Another method under development would be with a microneedle sampling method with a sensor array, which could measure interstitial fluid ketone levels and potentially also measure other analytes, such as glucose and lactate.…”

Section: The Principle Of Continuous Ketone Monitoringmentioning

confidence: 99%

Update on Measuring Ketones

Huang

Yeung

Bergenstal

et al. 2023

J Diabetes Sci Technol

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Ketone bodies are an energy substrate produced by the liver and used during states of low carbohydrate availability, such as fasting or prolonged exercise. High ketone concentrations can be present with insulin insufficiency and are a key finding in diabetic ketoacidosis (DKA). During states of insulin deficiency, lipolysis increases and a flood of circulating free fatty acids is converted in the liver into ketone bodies—mainly beta-hydroxybutyrate and acetoacetate. During DKA, beta-hydroxybutyrate is the predominant ketone in blood. As DKA resolves, beta-hydroxybutyrate is oxidized to acetoacetate, which is the predominant ketone in the urine. Because of this lag, a urine ketone test might be increasing even as DKA is resolving. Point-of-care tests are available for self-testing of blood ketones and urine ketones through measurement of beta-hydroxybutyrate and acetoacetate and are cleared by the US Food and Drug Administration (FDA). Acetone forms through spontaneous decarboxylation of acetoacetate and can be measured in exhaled breath, but currently no device is FDA-cleared for this purpose. Recently, technology has been announced for measuring beta-hydroxybutyrate in interstitial fluid. Measurement of ketones can be helpful to assess compliance with low carbohydrate diets; assessment of acidosis associated with alcohol use, in conjunction with SGLT2 inhibitors and immune checkpoint inhibitor therapy, both of which can increase the risk of DKA; and to identify DKA due to insulin deficiency. This article reviews the challenges and shortcomings of ketone testing in diabetes treatment and summarizes emerging trends in the measurement of ketones in the blood, urine, breath, and interstitial fluid.

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Section: The Principle Of Continuous Ketone Monitoringmentioning

confidence: 99%

Update on Measuring Ketones

Huang

Yeung

Bergenstal

et al. 2023

J Diabetes Sci Technol

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“…[1][2][3] It is reported that almost 500 million people are suffering from diabetes or prediabetes, and the influenced population is constantly expanding. 4 Significantly, due to the disturbance of the metabolism triggered by diabetes, diabetic patients are always tortured by many complications including kidney diseases, coronary heart disease, cerebrovascular disease, etc. 5 Lately, a-glucosidase (a-Glu) has been considered as one of the most crucial therapeutic targets of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Fluorometric and colorimetric dual-mode sensing of α-glucosidase based on aggregation-induced emission enhancement of AuNCs

Li,

Zhang,

Huang

et al. 2024

J. Mater. Chem. B

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“…Moreover, several studies on SBs-metal complexes showed their use as anti-Alzheimer agents [ 15 , 16 , 17 ], and their potential in the management of diabetes mellitus [ 18 ]. Some SBs derivatives have demonstrated α-glucosidase inhibition and antiglycation activity [ 19 , 20 ], whereas other derivatives were synthesized and used as fluorescent sensors for the diabetic biomarker beta-hydroxybutyrate (β-HB) [ 21 ]. Metal complexes of different metals with SBs have demonstrated a myriad of activities [ 22 , 23 ], and catalytic applications [ 24 ] in which metals are represented by Mo [ 25 ], Cu [ 26 , 27 , 28 ], Zr [ 29 , 30 , 31 ], Pd [ 32 ], Cu [ 33 ], Ni [ 34 ], Ru [ 35 ], Mn [ 36 ], Zn [ 37 , 38 ] and W [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

Sinicropi

Ceramella

Iacopetta

et al. 2022

IJMS

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Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.

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A highly selective turn-on schiff base fluorescent sensor for diabetic biomarker beta-hydroxybutyrate (β-HB)

Cited by 5 publications

References 25 publications

Update on Measuring Ketones

Update on Measuring Ketones

Fluorometric and colorimetric dual-mode sensing of α-glucosidase based on aggregation-induced emission enhancement of AuNCs

Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

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