A Highly Sensitive Spectrophotometric Method for the Determination of Some Phenothiazine Antipsychotics Using Chloramine-T and Indigocarmine

Abstract

A new simple, accurate and precise spectrophotometric method for the determination of six phenothiazine drugs in pure form and in dosage forms is described. The method is based on the oxidation of the studied drugs by a known excess of Chloramine-T in hydrochloric acid medium and subsequent determination of the unreacted oxidant by reacting it with indigocarmine in the same acid medium. The reacted oxidant corresponds to the drug content. The colored species exhibits maximum absorption at 610 nm. , respectively. The method is highly sensitive and suitable for 1 -15 µg ml -1 concentrations with the detection limits being in the range, 0.0651 -0.1724 µg ml -1 . The method was successfully applied to the studied drugs in their dosage forms. The results are reproducible within ±1% and compare favorably with those obtained by the procedures of the British Pharmacopeia.

Multi-walled carbon nanotubes with immobilised cobalt nanoparticle for modification of glassy carbon electrode: Application to sensitive voltammetric determination of thioridazine

“…Various techniques have been reported for the determination of TR, which include flow injection chemiluminescence (CL) (Kojlo et al, 2000;Li et al, 2007), spectrophotometric (Taha et al, 1983;Basavaiah and Swamy, 2001), spectrofluorimetric (Mohamed et al, -Kosior et al, 2006) and HPLC (Bhushan and Gupta, 2006). However, these methods suffer from disadvantages such as high costs, long analysis times and requirement for sample pretreatments, and in some cases, low sensitivity and selectivity that makes them unsuitable for the analysis of trace amounts of TR in pharmaceutical and clinical samples.…”

Characterization of indigo carmine with surface‐enhanced resonance Raman spectroscopy (SERRS) using silver colloids and island films, and theoretical calculations

“…19 In this case, E132 can be used for the detection of adenomas 20 and for the determination of antipsychotic drugs. 21 Several colorimetric studies show that E132 can be used as a reagent to measure the ozone concentration. 22,23 N. Peica and W. Kiefer Vibrational spectroscopy is one of the most powerful and widely used tools in modern materials research.…”

Use of an Oxidation Reaction for the Quantitative Determination of Albendazole with Chloramine-T and Acid Dyes

“…The versatility of Chloramine-T as an analytical reagent can be gauged by its applications in the titrimetric [27][28][29][30][31][32][33] and spectrophotometric [34][35][36][37][38][39][40] determination of many oragnic compounds of therapeutic importance. The use depends mainly on its ability to effect the oxidation of diverse functional groups.…”