A histochemical and immunohistochemical study of extra‐ocular sebaceous carcinoma

Ansai, Shin‐ichi; Hashimoto, Hideki; Aoki, Takehiko; Hozumi, Yasukazu; Aso, Kazuo

doi:10.1111/j.1365-2559.1993.tb00090.x

Cited by 83 publications

(62 citation statements)

References 17 publications

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“…Strong reactivity to epithelial membrane antigen and human milk fat globules subclasses 1 and 2 has been demonstrated. 8 A sebaceous carcinoma of salivary gland origin was also considered in the differential diagnosis. Intrasalivary sebaceous carcinoma is an extremely rare, low-grade malignancy most often occurring in the parotid gland.…”

Section: Discussionmentioning

confidence: 99%

Postauricular sebaceous carcinoma arising in association with nevus sebaceus

Rinaggio

McGuff

Otto³

et al. 2002

Head & Neck

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Section: Discussionmentioning

confidence: 99%

Postauricular sebaceous carcinoma arising in association with nevus sebaceus

Rinaggio

McGuff

Otto³

et al. 2002

Head & Neck

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“…Studies have shown that epithelial membrane antigen, cytokeratin 7, CAM 5.2, and androgen receptors can be used to suggest sebaceous differentiation in specific diagnostic contexts with variable success. [12][13][14][15][16][17][18][19][20] A recent study investigated the use of antibodies directed against proteins associated with lipid droplets, known as the PAT or perilipin family including a monoclonal antibody to adipophilin and polyclonal antibodies to perilipin and TIP47/ PP17. 17 Adipophilin is reported to be expressed in cells of lactating mammary epithelium, adrenal cortex, male reproductive system (Sertoli and Leydig cells), steatotic hepatocytes in alcoholic cirrhosis, and liposarcomas.…”

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confidence: 99%

Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases

et al. 2010

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Adipophilin is a monoclonal antibody against a protein on the surface of intracellular lipid droplets, and it was recently shown to be expressed in sebocytes and sebaceous lesions. This study examines adipophilin expression in various sebaceous lesions and other cutaneous tumors with a clear cell histology that may mimic sebaceous differentiation. A total of 117 cutaneous clear cell lesions including 16 sebaceous adenomas, 25 sebaceous carcinomas, 8 basal cell carcinomas, 12 squamous cell carcinomas, 6 xanthomas, 10 xanthelasmas, 10 xanthogranulomas, 4 balloon cell nevi, 5 trichilemmomas, 8 clear cell hidradenomas, and 13 metastatic renal cell carcinomas were examined using immunohistochemistry for the expression of adipophilin. Of these 117 lesions, 42 (36%) were from the periocular region. Adipophilin was expressed in 16 of 16 (100%) sebaceous adenomas, 23 of 25 (92%) sebaceous carcinomas, 10 of 10 (100%) xanthelasmas, 9 of 10 (90%) xanthogranulomas, 6 of 6 (100%) xanthomas, and 9 of 13 (62.5%) metastatic renal cell carcinomas. The characteristic staining pattern differed between sebaceous and non-sebaceous tumors with the former showing a membranous vesicular pattern and the latter being more granular. Adipophilin expression was not seen in any of the other lesions with clear cell histology, basal cell carcinomas, or squamous cell carcinomas, including cases that had focal clear cell differentiation. Adipophilin can be valuable in an immunohistochemical panel when evaluating cutaneous lesions with clear cell histology as it identifies intracytoplasmic lipid vesicles in sebaceous and xanthomatous lesions. In periocular lesions, it is effective in helping to exclude basal cell carcinoma and squamous cell carcinoma when sebaceous carcinoma is under consideration. Adipophilin expression is not as useful for the differential diagnosis that includes metastatic renal cell carcinoma, a rare but important, diagnostic differential. The pattern of adipophilin reactivity is important to observe as membranous vesicular staining is suggestive of intracellular lipids whereas granular cytoplasmic reactivity is not. Modern Pathology (2010) 23, 567-573; doi:10.1038/modpathol.2010.1; published online 29 January 2010Keywords: adipophilin; sebaceous tumors; differential diagnosis Sebaceous carcinoma is a relatively uncommon tumor comprising 0.05% of all cutaneous malignancies, but is the second or third most common malignant eyelid tumor in most series accounting for 2-4% of periocular tumors. 1 Local recurrence complicates 6-29% of periocular sebaceous cell carcinomas. [2][3][4][5] Regional or distal metastases affect 14-25% of patients with an associated 5-year mortality ranging from 30 to 67% according to different reports. 2,4 Owing to its variable clinical appearance, sebaceous carcinoma mimics both benign processes, such as chalazions and blepharitis, and other malignant

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“…[28][29][30][31][32][33][34][35][36][37][38][39][40] Although ocular sebaceous carcinoma is said to have a predilection for Asians, this has not been our experience; this may reflect selection bias based upon our practice profiles, however. Patients classically develop painless nodules or papules along the eyelid margin or in palpebral conjunctiva.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…In practice, ocular sebaceous carcinoma is far more common than its extraocular counterpart, although both are aggressive and potentially lethal malignant neoplasms. [3][4][5][28][29][30][31][32][33][34][35][36][37][38][39] Figure 2 Sebaceoma. Sebaceoma is characterized by a diffuse admixture of germinative epithelia and sebocytes with no compartmentalized, organized pattern as seen in sebaceous hyperplasia and sebaceous adenoma (a).…”

Section: Introductionmentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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A histochemical and immunohistochemical study of extra‐ocular sebaceous carcinoma

Cited by 83 publications

References 17 publications

Postauricular sebaceous carcinoma arising in association with nevus sebaceus

Postauricular sebaceous carcinoma arising in association with nevus sebaceus

Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases

Malignant adnexal neoplasms

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