A histochemical study on condylar cartilage and glenoid fossa during mandibular advancement

Owtad, Payam; Potres, Zoe; Shen, Gang; Petocz, Peter; Darendeliler, M. Ali

doi:10.2319/021710-99.1

Cited by 27 publications

(36 citation statements)

References 28 publications

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“…Due to the morphological, anatomical, and structural similarities to human condyles and mandibles, the rat model was chosen for this study. [5] The findings of this study with respect to three parameters (A-B, A-D, and B-C) indicate that Group I showed significant mandibular and condylar growth without any external stimulus during T0-T1. This result suggests the role of condylar growth in growing rats.…”

Section: Discussionmentioning

confidence: 55%

Effects of bite-jumping appliances on mandibular advancement in growing rats: A radiographic study

Okşayan

Üçüncü

2014

Eur J Dent

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Objective:The aim was to evaluate the effects of the use of mandibular advancement appliances on mandibular growth in growing rats.Materials and Methods:Twenty-four 8-week-old male Wistar albino rats were randomly divided into two experimental groups (12 rats each): Group I was a control group, and Group II was the mandibular advancement appliance group. A functional bite-jumping appliance was used in Group II to promote mandibular advancement. Anatomical changes in the condyle and mandible were evaluated by comparing radiographic results from before and after the study, with angular and linear measurements. Friedman and Mann-Whitney U-tests were used in statistical analysis.Results:According to the radiographic results, the growth of mandibles and condyles in Group II was significantly greater than with the length of the condylar process (A-B) and distance from condyle to menton (A-D) variables (P < 0.05). In addition, Group I showed greater mandibular base growth than did Group II (P < 0.05).Conclusions:We conclude that the use of an intraoral bite-jumping appliance can stimulate condylar growth and increase sagittal mandibular advancement in growing rats.

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Section: Discussionmentioning

confidence: 55%

Effects of bite-jumping appliances on mandibular advancement in growing rats: A radiographic study

Okşayan

Üçüncü

2014

Eur J Dent

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“…Reportedly, cartilaginous tissue is present in the mandibular fossa or the continuous articular eminence of rats, 46,47 young monkeys. 48 Only a few studies have investigated whether this type of cartilage exists in the mandibular fossa of the human fetus.…”

Section: Discussionmentioning

confidence: 99%

An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses

et al. 2013

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Immunohistochemical localization of collagen types I, II, and X, aggrecan, versican, dentin matrix protein (DMP)-1, martix extracellular phosphoprotein (MEPE) were performed for Meckel’s cartilage, cranial base cartilage, and mandibular condylar cartilage in human midterm fetuses; staining patterns within the condylar cartilage were compared to those within other cartilaginous structures. Mandibular condylar cartilage contained aggrecan; it also had more type I collagen and a thicker hypertrophic cell layer than the other two types of cartilage; these three characteristics are similar to those of the secondary cartilage of rodents. MEPE immunoreactivity was first evident in the cartilage matrix of all types of cartilage in the human fetuses and in Meckel’s cartilage of mice and rats. MEPE immunoreactivity was enhanced in the deep layer of the hypertrophic cell layer and in the cartilaginous core of the bone trabeculae in the primary spongiosa. These results indicated that MEPE is a component of cartilage matrix and may be involved in cartilage mineralization. DMP-1 immunoreactivity first became evident in human bone lacunae walls and canaliculi; this pattern of expression was comparable to the pattern seen in rodents. In addition, chondroid bone was evident in the mandibular (glenoid) fossa of the temporal bone, and it had aggrecan, collagen types I and X, MEPE, and DMP-1 immunoreactivity; these findings indicated that chondroid bone in this region has phenotypic expression indicative of both hypertrophic chondrocytes and osteocytes.

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“…43 A further analysis involving Sprague-Dawley rats has highlighted upregulation of fibroblast growth related factor (FGF8) following mandibular advancement over periods ranging from 3 to 30 days. 44 Cellular enlargement and differentiation were observed in both the condylar cartilage and the glenoid fossa during treatment with bony apposition by endochondral ossification in the condyle and intra-membranous ossification in the glenoid fossa.…”

Section: 33mentioning

confidence: 99%

Biological basis for functional appliance therapy

Fleming

Lee

2016

Orthodontic Functional Appliances

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A histochemical study on condylar cartilage and glenoid fossa during mandibular advancement

Cited by 27 publications

References 28 publications

Effects of bite-jumping appliances on mandibular advancement in growing rats: A radiographic study

Effects of bite-jumping appliances on mandibular advancement in growing rats: A radiographic study

An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses

Biological basis for functional appliance therapy

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