A Histologic Study of Adverse Effects of Different Cosmetic Skin Fillers

Parada, Meire Brasil; Michalany, N. S.; Hassun, Karime Marques; Bagatin, Ediléia; Talarico, Sérgio

doi:10.1111/j.1540-9740.2005.04061.x

Cited by 38 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it contains trace amounts of bacterial proteins and is generally well tolerated, there have been rare reports of occasional allergic hypersensitivity reactions [3,4,5] and of long-term cutaneous adverse reactions displaying two different histological patterns, i.e. granulomatous and non-granulomatous [1,6,7,8]. These reactions may be due to the reformulation of Restylane in 1999 into a more purified HA raw material containing less bacterial protein.…”

Section: Introductionmentioning

confidence: 99%

Migrating Granulomatous Chronic Reaction from Hyaluronic Acid Skin Filler (Restylane): Review and Histopathological Study with Histochemical Stainings

Cecchi¹,

Spota

Frati³

et al. 2013

Dermatology

View full text Add to dashboard Cite

Background: A unique case is presented in whom an allergic reaction to Restylane filler, associated with migrating granulomas, persisted despite medical interventions. A histopathological study was requested for evidence at court. Methods: Hematoxylin-eosin, alcian blue and colloidal iron staining were applied to skin sample biopsies obtained 5 months and 3 years after the hyaluronic acid (HA) injection. Results: The histological staining highlighted the presence of the filler inside the foreign body granuloma and in the derma of a biopsy obtained after 5 months; a small amount of filler was discovered within a granulomatous reaction 3 years after the injection. Conclusions: Smaller fragments of HA display inflammatory, angiogenic and immune-stimulatory activities. Intradermal skin testing before the start of HA filler therapy, and before each subsequent injection, may prevent legal implications for the plastic surgeon. Informed consent to skin tests should be obtained.

show abstract

Section: Introductionmentioning

confidence: 99%

Migrating Granulomatous Chronic Reaction from Hyaluronic Acid Skin Filler (Restylane): Review and Histopathological Study with Histochemical Stainings

Cecchi¹,

Spota

Frati³

et al. 2013

Dermatology

View full text Add to dashboard Cite

show abstract

Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG)

Brahm

Lessel²,

Ditlev

et al. 2011

J Tissue Eng Regen Med

View full text Add to dashboard Cite

The polyacrylamide hydrogel (PAAG) Aquamid® (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non-physiological constituents very efficiently with the surrounding medium. The efflux (J, mole/(cm(2)× s), 25 °C, pH 7.2) of water (4.4 × 10(-5) ), chloride (2.4 × 10(-7) ), urea (1.0 × 10(-9) ), and glucose (1.1 × 10(-9) ) was 3-40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium.

show abstract