A histological study on the effect of experimentally induced hyperthyroidism on adult albino rat testis

Abo-Elnour, Rahma K.; El-Deeb, Dalia Fathy

doi:10.1097/01.ehx.0000421551.12384.16

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Previous studies showed that increased reactive oxygen species production in hyperthyroid tissues led to a rise in oxidative stress in the rat testis in addition to the decrease in PCNA expression (Venditti & Di Meo ; Zamoner et al . ; Abo‐Elnour & El‐Deeb ). Therefore, neonatal hypothyroidism apparently extends the period of Sertoli cell proliferation; and increases Sertoli cell numbers, testis weight and daily sperm production when becoming euthyroid.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyper‐ and hypothyroidism on the development and proliferation of testicular cells in prepubertal rats

Fadlalla

Wei

Fedail

et al. 2017

Animal Science Journal

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Thyroid hormones are important in the development and regulation of testes. This study was conducted to determine the effects of hyper- and hypothyroidism on testicular development in prepubertal rats aged 20-70 days. Weaning male rats (20 days old) until day 70 age were randomly divided into four groups: control, hyperthyroid (hyper-T), hypothyroid (hypo-T) and hypothyroid treated with thyroxine (T4) (hypo-T+T4). The results indicated that thyroid hormones caused a significant effect in body and testis weights, and food and water consumption. In addition there were changes in serum concentrations of tri-iodothyronine, T4, thyroid stimulating hormone (TSH) and testosterone. Histomorphology showed a significant decrease in seminiferous tubule diameter in hyper-T compared to the other groups. Leydig cell numbers showed a significant elevation in hyper-T but not in hypo-T groups. Immunostaining indicated that TSH receptor (TSHR), thyroid hormone receptors α/β (TRαβ) and proliferating cell nuclear antigen (PCNA) have the roles in testicular development. Our findings suggest that hyper- and hypo-thyroidism regulate testicular cell proliferation and spermatogenesis in prepubertal rats, indicating that expression of TSHR, TRαβ and PCNA may be regulated by thyroid hormones that are involved in testicular development; and that the administration of T4 to the hypo-T+T4 group leads to an improvement in the testicular condition.

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Section: Discussionmentioning

confidence: 99%

Effects of hyper‐ and hypothyroidism on the development and proliferation of testicular cells in prepubertal rats

Fadlalla

Wei

Fedail

et al. 2017

Animal Science Journal

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Resveratrol ameliorates atrazine-induced caspase-dependent apoptosis and fibrosis in the testis of adult albino rats

Hassanin,

Kamal,

Ismail

2024

Sci Rep

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Pesticides like atrazine which are frequently present in everyday surroundings, have adverse impacts on human health and may contribute to male infertility. The work aimed to analyze the histological and biochemical effects of atrazine on the testis in adult albino rats and whether co-administration with resveratrol could reverse the effect of atrazine. Forty adult male albino rats in good health participated in this study. They were categorized at random into four groups: the Group Ӏ received water through a gastric tube for two months every day, the Group ӀӀ received resveratrol (20 mg/kg body weight (b.w.)) through a gastric tube for two months every day, the Group ӀӀӀ received atrazine (50 mg/kg bw) through a gastric tube for two months every day, the Group ӀV received concomitant doses of atrazine and resveratrol for two months every day. The testes of the animals were then carefully removed and prepared for biochemical, immunohistochemical, light, and electron microscopic studies. Atrazine exposure led to a significant decrease in serum testosterone hormone level, upregulation of caspase 3 and iNOS mRNA levels, destructed seminiferous tubules with few sperms in their lumens, many collagen fibres accumulation in the tunica albuginea and the interstitium, abnormal morphology of some sperms as well as many vacuolations, and damaged mitochondria in the cytoplasm of many germ cells. Concomitant administration of resveratrol can improve these adverse effects. It was concluded that atrazine exposure is toxic to the testis and impairs male fertility in adult rat and coadministration of resveratrol guards against this toxicity.

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Histological Study on the Effect of Experimentally Induced Hyperthyroidism on Testes of Adult Albino Rats and Possible Ameliorating Role of L-carnitine

Hegazy

Morsy

Moawad

et al. 2020

Egyptian Journal of Histology

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A histological study on the effect of experimentally induced hyperthyroidism on adult albino rat testis

Cited by 4 publications

References 38 publications

Effects of hyper‐ and hypothyroidism on the development and proliferation of testicular cells in prepubertal rats

Effects of hyper‐ and hypothyroidism on the development and proliferation of testicular cells in prepubertal rats

Resveratrol ameliorates atrazine-induced caspase-dependent apoptosis and fibrosis in the testis of adult albino rats

Histological Study on the Effect of Experimentally Induced Hyperthyroidism on Testes of Adult Albino Rats and Possible Ameliorating Role of L-carnitine

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