A Holistic Evaluation of Articles on PD-1 and PD-L1 Published Between 1975 and 2017: A Bibliometric Analysis

Baş, Yılmaz; Şenel, Engin

doi:10.1177/1176935119852620

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Bibliometrics is a measurable informatic method that analyses the knowledge structure to obtain quantifiable data and to address the above limitation ( Guo et al, 2020 ; McElroy and Allen, 2020 ; Wang et al, 2020 ). Although there have been several bibliometric studies related to PD1 or PDL1, they usually only focused on some specific aspects such as documents on PD1/PDL1 molecule, anti-PD1/PDL1 therapy in China or for a single kind of cancer ( Zhao et al, 2018 ; Baş and Şenel, 2019 ; Gao et al, 2019 ; Ahn and Hwang, 2020 ; Li et al, 2021 ). Considering that the application of anti-PD1/PDL1 in various cancers is still in exploration, and researchers devote to explore more mechanism of PD1/PDL1 molecule to improve efficacy of immunotherapy, it is necessary to conduct an updated and more comprehensive bibliometric study.…”

Section: Introductionmentioning

confidence: 99%

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

et al. 2021

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The programmed death receptor 1 (PD1) and its ligand programmed death receptor ligand 1 (PDL1) are the most widely used immune checkpoints in cancer immunotherapy. The related literature shows the explosive growth trends due to the promising outcomes of tumor regression. The present study aimed to provide a comprehensive bibliometric analysis of the literature on anti-PD1/PDL1 from three perspectives including molecular mechanisms, randomized clinical trials (RCT), and meta-analysis, thus producing a knowledge map reflecting the status of the research, its historical evolution, and developmental trends in related research from 2000 to 2020. We included 11,971, 191, and 335 documents from the Web of Science Core Collection database, respectively, and adopted various bibliometric methods and techniques thereto. The study revealed the major research themes and emergent hotspots based on literature and citation data and outlined the top contributors in terms of journals and countries. The co-occurrence overlay of keywords and terms pertaining to the PD1/PDL1 molecule reflected the progress from the discovery of the PD1/PDL1 molecule to the clinical application of anti-PD1/PDL1. Immune-related adverse events (irAEs) formed a unique cluster in the term co-occurrence analysis of meta-analysis. The historical direct citation network of RCT indicated the development and transformation of cancers and therapy strategies. irAEs and the strategies of combination therapy might become a future focus of research in this cognate area. In summary, the bibliometric study provides a general overview of the landscape on anti-PD1/PDL1 research, allowing researchers to identify the potential opportunities and challenges therein.

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Section: Introductionmentioning

confidence: 99%

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

et al. 2021

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“…Cancer has been a popular topic of bibliometric analyses; these investigations have examined multiple types of cancer, technological impacts, translational medicine, and immunotherapy [1][2][3][4][5][6][7]. Whether broad or specific, the goals are to describe the landscape of cancer research.…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric Review of Publications on Oxidative Stress and Chemobrain: 1990–2019

McElroy

Allen

2020

Antioxidants

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Oxidative stress is considered one of the possible mechanisms behind chemobrain or the cognitive dysfunction persistent after chemotherapy treatment. Breast cancer patients have reported chemobrain symptoms since the 1990s. In this present bibliometric review, we employed the VOSviewer tool to describe the existing landscape on literature concerning oxidative stress, breast cancer chemotherapies, and chemobrain. As of 2019, 8799 papers were listed in the Web of Science database, with more than 900 papers published each year. As expected, terms relating to oxidative stress, mitochondria, breast cancer, and antioxidants have occurred very often in the literature throughout the years. In recent years, there has been an increase in the occurrence of terms related to nanomedicine. Only within the last decade do the keywords ‘brain’, ‘blood-brain barrier’, and ‘central nervous system’ appear, reflecting an increased interest in chemobrain. China has become the most prolific producer of oxidative stress and chemotherapy related papers in the last decade followed by the USA and India. In conclusion, the subject of oxidative stress as a mechanism behind chemotherapies’ toxicities is an active area of research.

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Programmed death ligand (PD-L1) expression in invasive squamous cell carcinoma of the uterine cervix: A cross-sectional observational study

Chaudhary,

Raju,

Sheela

et al. 2022

Cancer Research, Statistics, and Treatment

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Background: Normal cervical epithelium does not express programmed death ligand-1 (PD-L1) protein. Expression of PD-L1 has been reported in 50% cells of cervical carcinoma. Approximately 17% of adenocarcinomas and 35% of squamous cell carcinomas (SCC) of the cervix express PD-L1. Objectives: To determine the expression of PD-L1 in invasive SCC of the cervix and to correlate the expression with various clinicopathological parameters. Materials and Methods: This was a cross-sectional study conducted between July 2016 and June 2021 in the Department of Pathology, in collaboration with the Department of Obstetrics and Gynecology at the R. L. Jalappa Hospital and Research Center, Kolar, in South India. proportion of PD-L1 expression was evaluated on the biopsy specimens by immunohistochemistry (PD-L1 Antibody Biogenex AN921-M) and based on the PD-L1 positive cells, was scored as 0 (<5%), 1 (5–29%), 2 (30–59%), and 3 (>60%). We evaluated the association of PD-L1 expression with the clinicopathological parameters. Results: We included 90 cases of SCC of the cervix. The median age was 52.5 years (range, 30–74), with the majority of patients between the ages of 40–49 years. Overall, PD-L1 expression was noted in 66.7% cases of SCC of the cervix. PD-L1 marker expression increased with age, from 40–49 years (n = 14/28, 50%) to 70–79 years (n = 10/12, 83.3%); P = 0.037. PD-L1 expression was maximum (n = 40/47, 85.1%) in moderately differentiated SCC; there was a significant correlation between histological grade and PD-L1 expression; P < 0.001. There were no significant correlations between the PD-L1 expression and other clinicopathological parameters such as parity, clinical findings, disease stage, size of lesion, lymph node status, and overall survival. Conclusion: Two-thirds of cervical SCC cases express PD-L1. The PD-L1 expression is significantly associated with the patient’s age and the grade of the disease. Evaluation of PD-L1 expression in SCC of the cervix is important as anti-PD-L1/PD-1 immunotherapies can be used in PD-L1 positive cervical cancer.

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A Holistic Evaluation of Articles on PD-1 and PD-L1 Published Between 1975 and 2017: A Bibliometric Analysis

Cited by 3 publications

References 18 publications

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

A Bibliometric Review of Publications on Oxidative Stress and Chemobrain: 1990–2019

Programmed death ligand (PD-L1) expression in invasive squamous cell carcinoma of the uterine cervix: A cross-sectional observational study

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