A homogeneous electrochemical sensing platform based on DNAzyme walker for accurate detection of breast cancer exosomes

Pushing Forward the DNA Walkers in Connection with Tumor-Derived Extracellular Vesicles

“…Another recent example, Zhang et al improved the accuracy of DNA walker detection of tumor exosomes through double recognition of MUC1 protein and HER2 protein in breast cancer exosomes. 70 As illustrated in Figure 6C , the aptamer sensor induces enzymatic cleavage through double recognition, while the DNA walker’s continuous movement leads to the cleavage of a large number of substrate strands. This results in the release of large amounts of DNA fragments containing enzymes that catalyze the production of hydrogen peroxide (H 2 O 2 ) by oxidizing excess glucose.…”

“…Reprinted from Sensors and Actuat B Chem, volume 404, Zhang M, Zhang T, Mei W, et al A homogeneous electrochemical sensing platform based on DNAzyme walker for accurate detection of breast cancer exosomes. 135252, Copyright 2024, with permission from Elsevier 70.…”