2016
DOI: 10.3390/ijms17071015
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A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells

Abstract: According to the potential anti-hepatoma therapeutic effect of Schisandra chinensis polysaccharides presented in previous studies, a bioactive constituent, homogeneous Schisandra chinensis polysaccharide-0-1 (SCP-0-1), molecular weight (MW) circa 69.980 kDa, was isolated and purified. We assessed the efficacy of SCP-0-1 against human hepatocellular liver carcinoma (HepG2) cells to investigate the effects of its antitumour activity and molecular mechanisms. Anticancer activity was evaluated using microscopy, 3-… Show more

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Cited by 17 publications
(9 citation statements)
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“…Hsp90 is generally overexpressed in OS and promotes tumour progression through the stabilization of its oncogenic client proteins (Chen et al, 2016; Sottile & Nadin, 2018). Based on the results described above, zey significantly altered the expression of Hsp90 client proteins, such as Chk1, CyclinD, and p53.…”
Section: Resultsmentioning
confidence: 99%
“…Hsp90 is generally overexpressed in OS and promotes tumour progression through the stabilization of its oncogenic client proteins (Chen et al, 2016; Sottile & Nadin, 2018). Based on the results described above, zey significantly altered the expression of Hsp90 client proteins, such as Chk1, CyclinD, and p53.…”
Section: Resultsmentioning
confidence: 99%
“…Pro- or anti-apoptotic proteins and caspases that regulate apoptosis have been observed in several suicide system treatments ( 27 ). overall, the pro-apoptotic proteins Bax, cleaved caspase-3 or -9 were upregulated the and anti-apoptotic protein, Bcl-2 was downregulated when suicide systems were implemented ( 28 ). Strong expression of both caspase-3 and Bcl-2 in responses to the suicide system suggests that pathways involving caspases and the Bcl-2 family may be active in these systems ( 29 ).…”
Section: Discussionmentioning
confidence: 99%
“…Synergistic application of triptolide and celastrol can mitigate effect of increased HSP27 and HSP70, inhibit growth of cancer cells, and induce apoptosis in cancer cells ( Jiang et al, 2015 ). Homogeneous polysaccharide-0-1 (SCP-0-1) from Schisandra chinensis induces mitochondrial apoptosis in human hepatocellular liver carcinoma, a mechanism involved in the downregulation of HSP90 and inhibition of Akt pathway ( Chen et al, 2016 ). Patrinia heterophylla , a member of Valerianaceae family, inhibits expression of HSP90α to induce apoptosis in leukemia K562 cells ( Wei et al, 2012 ).…”
Section: Tcm Regulates Expression Of Hspsmentioning
confidence: 99%