A homogeneous polysaccharide from Lycium barbarum: Structural characterizations, anti-obesity effects and impacts on gut microbiota

Yu, Yang; Chang, Ying; Wu, Yi; Liu, Hairong; Liu, Qi-Shan; Kang, Zuzhe; Wu, Man; Yin, Hong; Duan, Jinyou

doi:10.1016/j.ijbiomac.2021.05.209

Cited by 106 publications

(57 citation statements)

References 79 publications

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“…Lycium barbarum, a plant of the Solanaceae family, is a valuable herbal medicine, rich in amino acids, proteins, carotenoids, flavonoids, betaine, taurine and vitamins, which nourishes the liver and kidney ( Kulczyński, & Gramza-Michałowska, 2016 ). L. barbarum polysaccharide (LBP) is the main active ingredient of Wolfberry, endowed with different biological activities, such as anti-tumors ( Wang et al, 2020 ), immunomodulation ( Liu et al, 2022 ), regulation of blood sugar and lipid metabolism ( Yang et al, 2021 ), improvement of osteoporosis ( Wang et al, 2019 ), and anti-radiation ( Zheng et al, 2021 ). Due to its rich flavor, L. barbarum has become a key research plant in the food and pharmaceutical industries ( Kulczyński, & Gramza-Michałowska, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and antioxidant properties of Lycium barbarum seed dreg polysaccharides prepared by continuous extraction

Zhang

et al. 2022

Food Chemistry: X

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Section: Introductionmentioning

confidence: 99%

Physicochemical and antioxidant properties of Lycium barbarum seed dreg polysaccharides prepared by continuous extraction

Zhang

et al. 2022

Food Chemistry: X

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“…Thus, metabolic health has become a key point in the therapy of NAFLD/NASH. LBP has been reported to be effective against insulin resistance by C57BL/6J mice consuming a high-fat diet as well as HepG2 cells [ 59 ], and also against obesity symptoms by altering the composition of intestinal flora as well as promoting the metabolism of SCFAs [ 60 ]. Similarly, aerobic exercise has also been demonstrated to improve metabolic abnormalities [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway

et al. 2022

Nutrients

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Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease (NAFLD). Either Lycium barbarum polysaccharide (LBP) or aerobic exercise (AE) has been reported to be beneficial to hepatic lipid metabolism. However, whether the combination of LBP with AE improves lipid accumulation of NASH remains unknown. Our study investigated the influence of 10 weeks of treatment of LBP, AE, and the combination (LBP plus AE) on high-fat-induced NASH in Sprague–Dawley rats. The results showed that LBP or AE reduced the severity of the NASH. LBP plus AE treatment more effectively ameliorated liver damage and lowered levels of serum lipid and inflammation. In addition, the combination can also regulate genes involved in hepatic fatty acid synthesis and oxidation. LBP plus AE activated AMPK, thereby increasing the expression of PPARα which controls hepatic fatty acid oxidation and its coactivator PGC-1α. Our study demonstrated the improvement of LBP plus AE on NASH via enhancing fatty acid oxidation (FAO) which was dependent on AMPK/PPARα/PGC-1α pathway.

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“…The homogeneous polysaccharide (LBP-W) was purified from crude Lycium barbarum polysaccharides (LBPs), and administration of 50 mg/kg LBP-W could improve obesity by modulating the composition of gut microbiota and the metabolism of SCFAs in C57BL/6 mice on a high fat diet. LBP-W intervention reversed the HFD-induced changes in Firmicutes and Bacteroides, and the ratio of Firmicutes/Bacteroides was noticeably reduced (p < 0.01) [33].…”

Section: Polysaccharidesmentioning

confidence: 90%

Natural Ingredients from Medicine Food Homology as Chemopreventive Reagents against Type 2 Diabetes Mellitus by Modulating Gut Microbiota Homoeostasis

Xia

Xiao

2021

Molecules

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Type 2 diabetes mellitus (T2DM) is a noteworthy worldwide public health problem. It represents a complex metabolic disorder, mainly characterized as hyperglycemia and lipid dysfunction. The gut microbiota dysbiosis has been proposed to play a role in the development of diabetes. Recently, there has been considerable interest in the use of medicine food homology (MFH) and functional food herbs (FF) to ameliorate diabetes and lead to a natural and healthy life. Hence, this review compiles some reports and findings to demonstrate that the practical use of the MFH/FF can modulate the homoeostasis of gut microbiota, thereby ameliorating the development of T2DM. The results provided useful data to support further investigation of the functional basis and application of MFH/FF to treat T2DM through maintaining intestinal homeostasis.

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A homogeneous polysaccharide from Lycium barbarum: Structural characterizations, anti-obesity effects and impacts on gut microbiota

Cited by 106 publications

References 79 publications

Physicochemical and antioxidant properties of Lycium barbarum seed dreg polysaccharides prepared by continuous extraction

Physicochemical and antioxidant properties of Lycium barbarum seed dreg polysaccharides prepared by continuous extraction

Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway

Natural Ingredients from Medicine Food Homology as Chemopreventive Reagents against Type 2 Diabetes Mellitus by Modulating Gut Microbiota Homoeostasis

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