A homogeneous sol particle immunoassay for human chorionic gonadotrophin using monoclonal antibodies

Leuvering, Jan H.W.; Goverde, B. C.; Thal, Piet J.H.M.; Schuurs, A.H.W.M.

doi:10.1016/0022-1759(83)90330-7

Cited by 57 publications

(17 citation statements)

References 8 publications

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“…Lateral flow immunoassays (LFIA) are immuno-chromatographic test strips designed to be easy to use, as has been exemplified by their success as pregnancy tests [100]. Many food manufacturers utilize LFIA to test their clean-in-place (CIP) procedures and to ensure that their production lines are free from allergens.…”

Section: Methods For Food Allergen Detection Using a Smartphone Readomentioning

confidence: 99%

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

2018

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In this critical review, we provide a comprehensive overview of immunochemical food allergen assays and detectors in the context of their user-friendliness, through their connection to smartphones. Smartphone-based analysis is centered around citizen science, putting analysis into the hands of the consumer. Food allergies represent a significant worldwide health concern and consumers should be able to analyze their foods, whenever and wherever they are, for allergen presence. Owing to the need for a scientific background, traditional laboratory-based detection methods are generally unsuitable for the consumer. Therefore, it is important to develop simple, safe, and rapid assays that can be linked with smartphones as detectors to improve user accessibility. Smartphones make excellent detection systems because of their cameras, embedded flash functions, portability, connectivity, and affordability. Therefore, this review has summarized traditional laboratory-based methods for food allergen detection such as enzyme-linked-immunosorbent assay, flow cytometry, and surface plasmon resonance, and the potential to modernize these methods by interfacing them with a smartphone readout system, based on the aforementioned smartphone characteristics. This is the first review focusing on smartphone-based food-allergen detection methods designed with the intention of being consumer-friendly. Graphical abstractA smartphone-based food allergen detection system in three easy steps (1) sample preparation, (2) allergen detection on a smartphone using antibodies, which then transmits the data wirelessly, (3) analytical results sent straight to smartphone Electronic supplementary materialThe online version of this article (10.1007/s00216-018-0989-7) contains supplementary material, which is available to authorized users.

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Section: Methods For Food Allergen Detection Using a Smartphone Readomentioning

confidence: 99%

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

2018

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“…3). Based on the detection of an optical peak induced by cluster aggregation a number of analytical devices were developed by Mirkin and coworkers [16,17,18] . All these assays have a unique advantage over ELISA being quick and simple single step assays but suffer from a lower sensitivity.…”

Section: Cluster and Biomoleculesmentioning

confidence: 99%

Cluster optical coding: from biochips to counterfeit security

Haglmueller¹,

Alguel²,

Mayer³

et al. 2004

SPIE Proceedings

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Spatially tuned resonant nano-clusters allow high local field enhancement when excited by electromagnetic radiation. A number of phenomena has been described and subsequently applied for the construction of novel nano-and bionano-devices. Easy to manufacture, cost efficient and high throughput transducers using metal cluster resonance technology are based on surface-enhancement of metal cluster light absorption (SEA). The optical phenomenon driving SEA in metal cluster films is the so-called anomalous absorption. At a well defined nanometric distance of a cluster to a mirror the reflected electromagnetic field has the same phase at the position of the absorbing cluster as the incident fields. This feedback mechanism strongly enhances the effective cluster absorption coefficient. Such a system is characterized by a narrow reflection minimum. Based on this SEA-phenomenon (licensed to and further developed by november AG) a number of commercial products has been constructed. Brandsealing R uses the patented SEA cluster technology to produce optical codings. Cluster SEA thin film systems show a characteristic color-flip effect and are extremely robust. Both properties are vital for application as a unique security feature. The specific narrow band multi-resonance of the cluster layers allow easy authentication of the optical code. This can be achieved with a hand-held reader being developed by november AG and Siemens AG. SEA features are machine-readable which makes them superior to comparable technologies. Cluster labels are available in two formats: as a label for tamper-proof product packaging, and as a direct label, where label and logo are permanently applied directly and unremovable to the product surface. Together with Infineon Technologies and HUECK FOLIEN, the SEA technology is currently developed as a direct label for e.g. SmartCards.

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“…As for a given interlayer distance the optimum phase is only given for a de®ned wavelength, the system is characterized by a spectroscopically narrow re¯ection minimum whose spectral position shifts sensitively with the interlayer thickness (Figs. 5,6) The optical characteristics of the sensor can be modelled by either the strati®ed medium theory [11] or the CPS theory developed by Chance, Prock, and Silbey. These theories focus either on optical thin ®lms or on a polarizable particle in vicinity to a metal surface.…”

Section: Surface Enhanced Metal Cluster Systemsmentioning

confidence: 99%

Metal Nano Clusters as Transducers for Bioaffinity Interactions

Schalkhammer

1998

Monatshefte fuer Chemie

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Metal clusters excited by electromagnetic radiation exhibit high local ®eld enhancement and nanoscale resonant behavior. Absorptive properties of these metal clusters bound to a surface are the basis of various new and highly promising setups to transduce biorecognitive interactions into an optical signal.Immunogold labelling and immunogold chromatography as well as SPR transduction of metal cluster binding have been successfully commercialized. Multilayered highly resonant systems have been proposed and recently realized employing a metal mirror, a polymer distance layer, a biomolecule interaction layer, and biorecognitively bound metal nano clusters. Experiments indicate a strong in¯uence of cluster symmetry and cluster shell on the strong re¯ection minima induced by the resonant behavior. Modi®ed clusters, clearly exhibit at least one additional narrow re¯ection minimum in the red or infrared region and therefore far away from spherical gold colloids (<520 nm). Glass-type metal clusters synthesized by interruption of the thermal step of Au 3 -reduction as well as metal-dielectric shell clusters synthesized by multiple shell deposition processes enables the shift to a near-mid IR resonance.It is possible to convert directly (without use of additional analysis steps) biorecognitive binding processes and catalytic activity of proteins by the application of surface enhanced clusters into a visible optical signal (color change of sensor surface). Disposable single step assays as well as multiuse-monitoring devices have been established employing e.g. lectin-sugar, antigen-antibody, protein-receptor, or DNA-DNA interactions.Zusammenfassung. Metallcluster, die durch elektromagnetische Strahlung angeregt werden, zeigen starke lokale Feldu Èberho Èhung und resonantes Verhalten. Absorptive Eigenschaften dieser Metallcluster, welche an oder nahe einer Ober¯a Èche gebunden sind, ko Ènnen als Basis neuartiger analytischer Meûsysteme dienen, welche biorekognitive Wechselwirkungen in ein optisches Signal umzuwandeln vermo Ègen.Immunogoldmarkierung, Immunogoldchromatographie und die SPR-Transduktion der biorekognitiven Bindung von Metallclustern an Ober¯a Èchen wurden bereits mit Erfolg kommerziell verwertet. Mehrschichtige hochresonante Systeme wurden zuerst theoretisch berechnet und in den letzten Jahren durch einen Aufbau aus metallischer Spiegelschicht, einer nanometerdicken Polymerschicht, einer biorekognitiven Interaktionsschicht und daran gebundenen metallischen Clustern realisiert. Experimentell konnte gezeigt werden, daû die Symmetrie und der schalenfo Èrmige Aufbau der Cluster einen starken Ein¯uû auf die Lage und das Auftreten von resonanten Absorptionsbanden hat. Insbesondere Cluster mit glasartig-amorpher Struktur zeigen ein schmalbandiges Re¯exionsminimum im Rot-bzw. IR-Bereich und liegen daher weit niederenergetischer als spha Èrische Goldkolloide (< 520 nm). Modi®zierte Metallcluster, welche durch Unterbrechen des thermischen Reduktionsschritts aus Au 3 -Lo Èsungen oder durch Metall-Dielektrikum-Schalenaufbau ...

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A homogeneous sol particle immunoassay for human chorionic gonadotrophin using monoclonal antibodies

Cited by 57 publications

References 8 publications

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

Consumer-friendly food allergen detection: moving towards smartphone-based immunoassays

Cluster optical coding: from biochips to counterfeit security

Metal Nano Clusters as Transducers for Bioaffinity Interactions

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