A homoisoflavanone from Ornithogalum longibracteatum (Ornithogaloideae: Hyacinthaceae)

Mulholland, Dulcie A.; Crouch, Neil R.; Pohl, Tracy; Ndlovu, E.

doi:10.1016/j.bse.2003.11.005

Cited by 16 publications

(3 citation statements)

References 16 publications

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“…Furthermore, the structure of 126 was later confirmed via chemical synthesis , by Yu’s research group. Of course, there were many other types of constituents reported in Ornithogalum plants, such as flavone and its glycosides, − sapocarotenoids, monoterpenes, triterpenes, and polysaccharides …”

Section: Phytochemical Studiesmentioning

confidence: 99%

Structure, Bioactivity, and Chemical Synthesis of OSW-1 and Other Steroidal Glycosides in the Genus Ornithogalum

Tang

Duan

et al. 2013

Chem. Rev.

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Section: Phytochemical Studiesmentioning

confidence: 99%

Structure, Bioactivity, and Chemical Synthesis of OSW-1 and Other Steroidal Glycosides in the Genus Ornithogalum

Tang

Duan

et al. 2013

Chem. Rev.

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“…Concern about the potential toxicity of O. longibracteatum has been raised (Van Wyk et al, 2002) and toxicity evaluations have provided unequivocal results (Mulholland et al, 2004). The bulb that was extracted for this study was approximately three years old and had flowered during this time.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and Cytotoxicity Screening of Five Medicinal Plants Used by Traditional African Health Practitioners in the Nelson Mandela Metropole, South Africa

Huyssteen¹,

Milne²,

Campbell³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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Diabetes mellitus is a growing problem in South Africa and of concern to traditional African health practitioners in the Nelson Mandela Metropole, because they experience a high incidence of diabetic cases in their practices. A collaborative research project with these practitioners focused on the screening of Bulbine frutescens, Ornithogalum longibracteatum, Ruta graveolens, Tarchonanthus camphoratus and Tulbaghia violacea for antidiabetic and cytotoxic potential. In vitro glucose utilisation assays with Chang liver cells and C2C12 muscle cells, and growth inhibition assays with Chang liver cells were conducted. The aqueous extracts of Bulbine frutescens (143.5%), Ornithogalum longibracteatum (131.9%) and Tarchonanthus camphoratus (131.5%) showed significant increased glucose utilisation activity in Chang liver cells. The ethanol extracts of Ruta graveolens (136.9%) and Tulbaghia violacea (140.5%) produced the highest increase in glucose utilisation in C2C12 muscle cells. The ethanol extract of Bulbine frutescens produced the most pronounced growth inhibition (33.3%) on Chang liver cells. These findings highlight the potential for the use of traditional remedies in the future for the management of diabetes and it is recommended that combinations of these plants be tested in future.

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“…revealed one major compound, the homoisoavanone 711. 403 The water extract of the bulbs produced a signicant increase in glucose utilisation in Chang liver cells. 404 Stellarioides longibracteata was introduced to China many years ago and it is used in Chinese folk medicine to treat cancer, as an antimicrobial, anti-inammatory and to treat hepatitis and parotitis.…”

Section: The Ornithogaloideaementioning

confidence: 99%

The chemistry and biological activity of the Hyacinthaceae

2013

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The Hyacinthaceae (sensu APGII), with approximately 900 species in about 70 genera, can be divided into three main subfamilies, the Hyacinthoideae, the Urgineoideae and the Ornithogaloideae, with a small fourth subfamily the Oziroëoideae, restricted to South America. The plants included in this family have long been used in traditional medicine for a wide range of medicinal applications. This, together with some significant toxicity to livestock has led to the chemical composition of many of the species being investigated. The compounds found are, for the most part, subfamily-restricted, with homoisoflavanones and spirocyclic nortriterpenoids characterising the Hyacinthoideae, bufadienolides characterising the Urgineoideae, and cardenolides and steroidal glycosides characterising the Ornithogaloideae. The phytochemical profiles of 38 genera of the Hyacinthaceae will be discussed as well as any biological activity associated with both crude extracts and compounds isolated. The Hyacinthaceae of southern Africa were last reviewed in 2000 (T. S. Pohl, N. R. Crouch and D. A. Mulholland, Curr. Org. Chem., 2000, 4, 1287-1324; ref. 1); the current contribution considers the family at a global level.

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A homoisoflavanone from Ornithogalum longibracteatum (Ornithogaloideae: Hyacinthaceae)

Cited by 16 publications

References 16 publications

Structure, Bioactivity, and Chemical Synthesis of OSW-1 and Other Steroidal Glycosides in the Genus Ornithogalum

Structure, Bioactivity, and Chemical Synthesis of OSW-1 and Other Steroidal Glycosides in the Genus Ornithogalum

Antidiabetic and Cytotoxicity Screening of Five Medicinal Plants Used by Traditional African Health Practitioners in the Nelson Mandela Metropole, South Africa

The chemistry and biological activity of the Hyacinthaceae

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