A Huge Benign Phyllodes Tumour of the Breast: a Rare Entity

Paryani, Jeetendar

doi:10.1007/s13193-019-00911-y

Cited by 4 publications

(5 citation statements)

References 11 publications

(38 reference statements)

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“…The size of phyllodes tumors is quite variable but the median size is usually around 4 cm. The mass exceeding 10 cm is considered as a giant tumor [ 3 ]. The giant tumors distort the breast and may cause skin manifestations, such as an ulceration [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: a case report

Niyonkuru,

Nisabwe,

Sami

et al. 2023

Journal of Surgical Case Reports

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Phyllodes tumor is a rare tumor of the breast, which encompasses both stromal and epithelial components. In these components, metaplastic changes can be observed occasionally. We report the case of a 51-year-old woman nulligest menopaused who presented a huge mass, largely ulcerated in her right breast. The radiological examination revealed a large tumor with microcalcifications classified as Breast Imaging and Reporting Data System Category 5. The patient undergone right mastectomy and the histological analysis revealed benign phyllodes tumor with cystic squamous metaplasia. Therefore, we aim to present this uncommon event occasionally occurring in phyllodes tumor of the breast.

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Section: Discussionmentioning

confidence: 99%

“…can reach up to 60 cm) [ 2 ]. About 20% of all phyllodes tumors are larger than 10 cm in diameter and are considered as giant phyllodes tumors [ 1 , 3 ]. Rarely, metaplastic changes can occur both in the epithelial and stromal component of those tumors.…”

Section: Introductionmentioning

confidence: 99%

Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: a case report

Niyonkuru,

Nisabwe,

Sami

et al. 2023

Journal of Surgical Case Reports

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“…When a PT has a diameter above 10 cm, it can be classified as a giant PT [ 12 ]. Most of the cases in our review presented local signs of inflammation, venous congestion [ 13 , 14 ], bleeding [ 10 , 15 , 16 ], “peau d’orange” [ 17 , 18 ] or even necrosis or skin ulcers [ 7 , 10 , 14 , 15 , 16 , 19 , 20 , 21 ] while others had no other clinical manifestation than the enlargement of the affected breast [ 22 , 23 , 24 , 25 ]. Local complications are attributed to the increased pressure that the rapid tumoral growth exerts on the skin but can be difficult to interpret since they are encountered also in malignancy [ 26 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Diagnostic difficulties in giant benign phyllodes tumor

Matei

Mehedinţu-Ionescu²,

Paitici³

et al. 2022

Rom J Morphol Embryol

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Phyllodes tumors (PTs) are rare tumors of the breast, which encompass both stromal and epithelial components. The maximum incidence is in the fourth decade of life. Most of these tumors are benign, but about one third can be malignant acting as sarcomas. Due to their rarity and atypical clinical behavior (especially for the giant ones), the management of these tumors is usually difficult. We report a case of a 24-year-old woman who presented in the Department of Oncology for rapid increase in volume of the left breast. She had no personal pathological or family history. Initial clinical exam showed a large irregular mass in the left breast of approximately 30 cm and palpable lymph nodes in the ipsilateral axilla. A core needle biopsy for the tumor was performed with histopathological (HP) result that revealed an aspect suggesting fibroadenoma/PT. Contrast-enhanced computed tomography (CT) scan identified lymph node enlargement in the left axilla and a peripheral nodule in the lung about 5.5/3.4 mm with no specific features. The patient was then transferred to the Department of Surgery, where left mastectomy and axillary lymph node sampling were performed. HP result of the surgical specimens confirmed the presence of both fibroadenoma and PT, with clear margins above 1 cm, but recommended immunohistochemistry (IHC) to clearly specify benign versus borderline type. Five lymph nodes out of six resected presented microscopic reactive changes. We performed a search of literature using the keywords "giant", "benign" and "phyllodes". The results were used to summarize and discuss some of the main features of this type of tumors as well as diagnostic and therapeutic difficulties.

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“…World Health Organization (WHO) classi es phyllodes tumors according to histopathological features, including tumor margins, stromal cellularity, stromal cell atypia, mitotic activity, stromal overgrowth and the presence of malignant heterologous elements [2].Three groups can be indeed determined benign, borderline and malignant. Phyllodes tumors vary in size (i.e., can reach up to 60 cm) [3]. About 20% of all phyllodes tumors are larger than 10 cm in diameter and are considered as giant phyllodes tumors [1,4].…”

Section: Introductionmentioning

confidence: 99%

Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: A case report

Niyonkuru

Nisabwe

Zineb

et al. 2023

Preprint

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Background Phyllodes tumor is rare tumor of the breast, which encompasses both stromal and epithelial components. In these components, metaplastic changes can be observed occasionally. Case presentation We report the case of a 51-year-old woman nulligest menopaused who presented a huge mass, largely ulcerated in her right breast. The radiological examination revealed a large tumor with microcalicifications classified as Breast Imaging and Reporting Data System [BI-RADS] category 5. The patient undergone right mastectomy and the histological analysis revealed benign phyllodes tumor with cystic squamous metaplasia. Conclusions It is essential to be aware of this uncommon event in order to avoid misdiagnosis.

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A Huge Benign Phyllodes Tumour of the Breast: a Rare Entity

Cited by 4 publications

References 11 publications

Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: a case report

Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: a case report

Diagnostic difficulties in giant benign phyllodes tumor

Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: A case report

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