A human infection case with avian-origin H10N3 influenza virus

Jing, Ji-Sheng; Wang, Longyu; Wang, Guocheng; Dai, Zaodong; Ren, Weigang; Yi, Changhua; Wei, Jian; Xu, Chuanjun

doi:10.21037/qims-21-592

Cited by 10 publications

(11 citation statements)

References 6 publications

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“…Three cases of human infection with H10N8 virus were first reported in China in 2013, of which two were fatal cases ( 38 – 40 ). In 2021, an avian-origin H10N3 virus caused human infection in China, resulting in severe pneumonia ( 41 , 42 ). Liu et al found that H10N3 reassortants isolated from chickens in eastern China showed high pathogenicity in mice and could be transmitted between chickens and guinea pigs ( 43 ).…”

Section: Introductionmentioning

confidence: 99%

Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

Wang

Zhang

et al. 2022

Microbiol Spectr

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Section: Introductionmentioning

confidence: 99%

Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

Wang

Zhang

et al. 2022

Microbiol Spectr

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“…In 2010, poultry abattoir workers were reported to be infected with an IAV of the H10 subtype, following an outbreak of LPAIV H10N7 in an Australian chicken farm [99]. Since then, three more cases that were caused by an H10N8 and H10N3 virus were documented in China [100][101][102]. Notably, AIVs of the H10 subtype are highly diverse and are regularly found in poultry, ducks, and in live bird-markets [103][104][105].…”

Section: Avian Reservoir Speciesmentioning

confidence: 99%

Influenza A Viruses and Zoonotic Events—Are We Creating Our Own Reservoirs?

Kessler

Harder

Schwemmle

et al. 2021

Viruses

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Zoonotic infections of humans with influenza A viruses (IAVs) from animal reservoirs can result in severe disease in individuals and, in rare cases, lead to pandemic outbreaks; this is exemplified by numerous cases of human infection with avian IAVs (AIVs) and the 2009 swine influenza pandemic. In fact, zoonotic transmissions are strongly facilitated by manmade reservoirs that were created through the intensification and industrialization of livestock farming. This can be witnessed by the repeated introduction of IAVs from natural reservoirs of aquatic wild bird metapopulations into swine and poultry, and the accompanied emergence of partially- or fully-adapted human pathogenic viruses. On the other side, human adapted IAV have been (and still are) introduced into livestock by reverse zoonotic transmission. This link to manmade reservoirs was also observed before the 20th century, when horses seemed to have been an important reservoir for IAVs but lost relevance when the populations declined due to increasing industrialization. Therefore, to reduce zoonotic events, it is important to control the spread of IAV within these animal reservoirs, for example with efficient vaccination strategies, but also to critically surveil the different manmade reservoirs to evaluate the emergence of new IAV strains with pandemic potential.

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“…Among the 18 HA subtypes, six subtypes have caused a substantial number of human infections (H1, H2, H3, H5, H7, and H9) 5–7 ; however, only three subtypes (H1, H2, and H3) have crossed the species and caused pandemics in humans 1,2 . For other HA subtypes, only sporadic spillover from avian to human has been observed (e.g., the H6 8 and H10 9,10 subtypes).…”

Section: Introductionmentioning

confidence: 99%

“…H10N8 viruses caused three human infections between 2013 and 2014; however, no additional H10N8 human case was reported thereafter. Then, in 2021, an H10N3 human case was reported in Jiangsu, China, raising the concern of cross‐species transmission of H10 virus 10,21–23 . This case raised questions as to how the H10N3 virus has evolved to infect humans since 2014, and how much risk do H10N3 viruses pose to the poultry industry and public health.…”

Section: Introductionmentioning

confidence: 99%

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Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021

Zhang

Shi

Cui

et al. 2023

Journal of Medical Virology

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The H10 subtypes of avian influenza viruses pose a continual threat to the poultry industry and human health. The sporadic spillover of H10 subtypes viruses from poultry to humans is represented by the H10N8 human cases in 2013 and the recent H10N3 human infection in 2021. However, the genesis and characteristics of the recent reassortment H10N3 viruses have not been systemically investigated. In this study, we characterized 20 H10N3 viruses isolated in live poultry markets during routine nationwide surveillance in China from 2014 to 2021. The viruses in the recent reassortant genotype acquired their hemagglutinin (HA) and neuraminidase (NA) genes from the duck H10 viruses and H7N3 viruses, respectively, whereas the internal genes were derived from chicken H9N2 viruses as early as 2019. Receptorbinding analysis indicated that two of the tested H10N3 viruses had a higher affinity for human-type receptors than for avian-type receptors, highlighting the potential risk of avian-to-human transmission. Animal studies showed that only viruses belonging to the recent reassortant genotype were pathogenic in mice; two tested viruses transmitted via direct contact and one virus transmitted by respiratory droplets in guinea pigs, though with limited efficiency. These findings emphasize the need for enhanced surveillance of H10N3 viruses.

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A human infection case with avian-origin H10N3 influenza virus

Cited by 10 publications

References 6 publications

Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

Influenza A Viruses and Zoonotic Events—Are We Creating Our Own Reservoirs?

Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021

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