KeywordsQuail chick, nutritional requirement, uniform design, neural network.Submitted: September/2013 Approved: June/2014 ABSTRACT A uniform design (UD) was used to construct models to explain the growth response of Japanese quails to dietary metabolizable energy (ME), and digestible methionine (dMet) and lysine (dLys) under tropical condition. In total, 100 floor pens with seven birds each were fed 25 UD different diets containing 25 ME (2808-3092 kcal/kg), dMet (0.31-0.49% of diet), and dLys (0.91-1.39% of diet) levels from 7 to 14 d of age. A platform of artificial neural network based on UD (ANN-UD) was generated to describe the growth response of the birds to dietary inputs using random search. Artificial neural networks of body weight gain (BWG) and feed conversion ratio (FCR) were optimized using random search algorithm. The optimization the ANN-UD results showed that maximum BWG may be achieved with 2995 kcal ME/kg, 0.45% dMet, and 1.18% dLys of diet; and minimum FCR may be obtained with 3000 kcal ME/kg, 0.45% dMet, and 1.17% dLys of diet. The result of this study showed that a ANN and UD hybrid model can be used successfully to optimize the nutritional requirements of quail chicks.